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We present an organoid regeneration assay in which freshly dissociated human mammary epithelial cells from healthy donors are grown in adherent/rigid or floating/compliant collagen I gels. In both conditions, luminal progenitors (CD49f+EpCAM+) form spheres, whereas basal cells (CD49fhiEpCAM-) genera...
ORGANISM(S): Homo sapiens 
More than half of the ∼20,000 protein-encoding human genes have at least one paralog. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to a subset of paralogous proteins. Here, we explore whether such covalent compound-cysteine interactions can be used to di...
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD053077 | Pride
This is to explore potential functional effects of CCNE1(:CDK2) ligands and compare them side by side.
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD048328 | Pride
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