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TranscriptomicsSirt1, p53 and p38MAPK are crucial regulators of detrimental phenotypes of ESCs with Max expression ablation
Ablation of expression of the Max gene encoding a Myc protein partner in ES cells provoked two major phenomena, i.e. loss of pluripotency and apoptotic cell death. We found that nicotinamide (Nam) significantly alleviates these Max expression ablation-coupled phenotypes in ES cells. To see the allev...
ORGANISM(S): Mus musculus 
2012-08-28 | E-GEOD-37917 | biostudies-arrayexpress
TranscriptomicsEffect of ablation of Max gene expression on ES cells cultured under conventional or 2i/Nam condition.
c-Myc is one of key players that are crucially involved in maintaining the undifferentiated state and the self-renewal of ESCs. To understand the mechanism by which c-Myc helps preserve these prominent characteristics of ESCs, we generated null-ES cells for the Max gene, which encodes the best chara...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-27881 | biostudies-arrayexpress
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