Sort   by:  
 Page size 
MetabolomicsCombined transcriptome and metabolome analysis reveals the regulatory network of histidine kinase QseC in the two-component system of Glaesserella parasuis
Glaesserella parasuis is the causative agent of Glässer's disease in pigs, which can lead to polyserositis, arthritis, and meningitis. This study used transcriptome and metabolomics sequencing techniques to investigate the mechanism of action of qseC gene in Glaesserella parasuis. Transmission elect...
2025-08-11 | MTBLS12504 | MetaboLights
MetabolomicsHistidine improves Hashimoto thyroiditis by inhibiting the production of Neutrophil Txtracellular Traps

Objective: Metabolite abnormalities are potentially implicated in pathogenesis of Hashimoto’s thyroiditis (HT). An in-depth study of the relationship between HT and small molecule metabolites, as well as its pathogenesis, can help enhance the diagnosis, prognosis, and treatment of HT patients.

2025-10-12 | MTBLS12333 | MetaboLights
MetabolomicsRaw data from targeted energy metabolomics analysis of L-histidine-treated RAW264.7 cells

With the monophasic variant of Salmonella Typhimurium (S. 4,[5],12:i-) emerging as one of the most prevalent serotypes, multidrug resistance has become an increasingly serious clinical challenge. Conventional antibiotic therapy is further constrained by adverse effects, including resistance selec...

2026-10-04 | MTBLS15914 | MetaboLights
TranscriptomicsThe cell envelope stress response mediated by the LiaFSRLm three-component system of Listeria monocytogenes is controlled via the phosphatase activity of the bifunctional histidine kinase LiaSLm
Most members of the phylum Firmicutes harbor a two-component system, LiaSR, which is involved in the response to cell envelope stress elicited most notably by inhibitors of the lipid II cycle. In all LiaSR systems studied in detail LiaSR-mediated signal transduction was shown to be negatively contro...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-11-16 | E-GEOD-24107 | biostudies-arrayexpress
TranscriptomicsHistidine-Kinase Activity of the Ethylene Receptor ETR1 Facilitates the Ethylene Response in Arabidopsis
Ethylene response in Arabidopsis with wild-type or kinase-inactive ETR1
ORGANISM(S): Arabidopsis thaliana 
2012-04-01 | E-MEXP-3574 | biostudies-arrayexpress
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
TranscriptomicsExpression data from isolated peritoneal macrophages treated with Histidine-rich glycoprotein
Histidine-rich glycoprotein (HRG) is a 75 kDa heparin-binding plasma protein which has been implicated in regulation of tumor angiogenesis and growth. To exert some of its biological functions, HRG acts on macrophages.This study was performed to assess changes in gene expression in peritoneal macrop...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-34164 | biostudies-arrayexpress
TranscriptomicsIdentification of a target gene and activating stimulus for the YpdA/YpdB histidine kinase/response regulator system in Escherichia coli
To identify YpdB-regulated genes, the transcriptome profiles of E. coli cells overproducing either the response regulator (RR) YpdB or the RR YehS (control) were comparatively analyzed. The expression level of 15 genes varied more than 1.9-fold.
ORGANISM(S): Escherichia coli 
2012-10-30 | E-MTAB-1347 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Clostridium acetobutylicum ATCC 55025, histidine kinase Cac3319 and Cac0437 inactivated strains.
The goal of this experiment is compare gene expression profiles between C. acetobutylicum ATCC 55025, histidine kinase cac3319 and cac0437 inactivated strains to determine the pleiotropic and distinctive functions of histidine kinases on cell differentiation and cellular metabolism. Samples for tota...
ORGANISM(S): Clostridium acetobutylicum 
2019-05-01 | E-MTAB-7341 | biostudies-arrayexpress
Sort   by:  
 Page size