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MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
TranscriptomicsExpression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
Analysis of histone acetyl transferases (HATs) from the MYST and GNAT families in S. pombe to identify functional differences or overlap with regard to gene expression. Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family). Mutants showed distinct phenotypes which were repres...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-19 | E-GEOD-17298 | biostudies-arrayexpress
TranscriptomicsGenome-wide enrichment of Gcn5 and H3K18/H4K16 acetylation under physiological change of stress adaptation and stress recovery
The data provide information of Gcn5 enrichment, H3K18 and H4K16 acetylation level and Histone H3 density for 5 different physioloigcal conditions during stress adpatation and stress recovery (normal growth, during stress adaptation, after stress adaptation, under stress recovery, after stress rec...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-22 | E-GEOD-36600 | biostudies-arrayexpress
TranscriptomicsToxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in response to stresses that prompt development into ...
ORGANISM(S): Toxoplasma gondii 
2011-05-25 | E-GEOD-22100 | biostudies-arrayexpress
TranscriptomicsRare Allele of A Novel Histone H4 Acetyltransferase Enhances Grain Weight, Yield and Plant Biomass Presumably Through the Regulation of Transcription
Grain weight is an important crop yield component; however, its underlying regulatory mechanisms are largely unknown. Here, we identify a grain-weight quantitative trait locus (QTL) encoding a new-type GNAT-like protein that harbors intrinsic histone acetyltransferase activity (OsglHAT1). Our geneti...
ORGANISM(S): Oryza sativa Japonica Group 
2015-02-10 | E-GEOD-62554 | biostudies-arrayexpress
GenomicsChIP-seq of MYST acetyltransferases
Histone acetyltransferases (HAT) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we characterize native HAT complexes assembled by the BRPF-family of scaffold proteins. Their PHD-ZnKnuckle-PHD domain is essential for binding chromatin...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-47190 | biostudies-arrayexpress
GenomicsGenome wide mapping of histone acetyltransferase MOF binding in murine ES cells (sequencing)
We report the application of illumina sequencing technology for high-throughput profiling of histone acetyltransferase Mof in mouse embryonic stem cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse emb...
ORGANISM(S): Mus musculus 
2012-08-09 | E-GEOD-37268 | biostudies-arrayexpress
TranscriptomicsDeletion of Clr3 restores expression of a subset of genes in gcn5- mutant cells
Histone acetylation and deacetylation is important for gene regulation. The histone acetyltransferase, Gcn5, is a known activator of transcriptional initiation that is recruited to gene promoters. Here we map genome-wide levels of Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predom...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-24 | E-GEOD-13817 | biostudies-arrayexpress
OtherData for: Short-chain fatty acids activate acetyltransferase p300/CBP
The short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs have been traced to changes in epigenetic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-12 | MSV000087800 | MassIVE
ProteomicsYang_NuA4_TIP60_structural_features
This submission contains the mass spectrometry files for the manuscript by Zhenlin Yang et al. that describes the unique structural features of the NuA4/TIP60 acetyltransferase and chromatin remodeling complex. MS experiments were performed from TAP purified complexes from K562 cells and MS files we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-02 | MSV000093280 | MassIVE
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