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ProteomicsAP-MS analysis of human histone deacetylase interactions in CEM-T cells
Affinity purification-mass spectrometry (AP-MS) datasets of eleven human histone deacetylases (HDACs). Affinity-tagged (GFP) HDACs were expressed in a human CEM-T cell line. For label-free analysis, proteins were digested by trypsin in-solution and peptides separated across a linear 180 min gradient...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079563 | MassIVE
TranscriptomicsTranscription profiling of embryonic stem cells from wild type and histone deacetylase 1 (HDAC1) knock out mice to identify putative HDAC1 target genes.
Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5583 | biostudies-arrayexpress
GenomicsHistone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq)
We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. HDAC3 enriched gen...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33596 | biostudies-arrayexpress
TranscriptomicsThe Histone Deacetylase Rpd3p Coordinates Transient Changes in Genomic Expression in Response to Acute Stress
To characterize the role of chromatin remodeling proteins in mediating stress-activated expression changes, whole-genome expression was followed in wild-type and mutant cells (including strains lacking the histone deacetylase Rpd3p, associated Rpd3p proteins, and the transcription factors Msn2p and ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-05-20 | E-GEOD-9108 | biostudies-arrayexpress
TranscriptomicsSelective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition
Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Previous studies have shown that a reduction on histone deacetylase (HDAC) activity results on the enhancement of ...
ORGANISM(S): Mus musculus 
2010-09-17 | E-GEOD-17731 | biostudies-arrayexpress
GenomicsGenome-wide maps of histone modifications in Arabidopsis thaliana
Histone acetylation and methylation regulate gene expression in eukaryotes, but their effects on the transcriptome of a multicellular organism and on the transcriptomic divergence between species are still poorly understood. Here we present the first genome-wide 1-bp resolution maps of histone acety...
ORGANISM(S): Arabidopsis thaliana 
2011-02-02 | E-GEOD-22276 | biostudies-arrayexpress
TranscriptomicsA Multi-loop, Double-cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors
Implementation of a complex design for a microarray experiment on resistance mechanisms of histone deacetylase inhibitors (HDACI). To improve our understanding of the underlying mechanism of HDACI resistance in prostate cancer cells, we designed a novel ‘‘multiple-loop, double-cube’’ cDNA microarray...
ORGANISM(S): Homo sapiens 
2011-12-17 | E-GEOD-34452 | biostudies-arrayexpress
Transcriptomicsnuclear run-on sequencing analysis of histone deacetylase inhibition
nuclear run-on sequencing analysis of histone deacetylase inhibition
ORGANISM(S): Homo sapiens 
2012-11-30 | E-MTAB-668 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and mutant axel-4 Arabidopsis seedlings
A mutant screen was conducted in Arabidopsis that was based on deregulated expression of auxin-responsive transgenes. Two different tightly regulated (i.e., very low expression in the absence of auxin treatment and very high expression after exogenous auxin treatment) auxin-responsive promoters were...
ORGANISM(S): Arabidopsis thaliana 
2007-05-04 | E-SMDB-4012 | biostudies-arrayexpress
ProteomicsAn unexpected histone-binding activity for the MIER1 histone deacetylase complex suggests a potential chaperone function.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the deacetylase subunit, these complexes typically cont...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD036303 | Pride
Methylation Deacetylase Histone 
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