Sort   by:  
 Page size 
MetabolomicsMolecular changes in cancer cells exposed to an HDAC inhibitor: A metabolomics approach
Histone deacetylase (HDAC) inhibitors are part of a new generation of epigenetic drugs for cancer treatment. It is known that histone acetylation plays a key role in controlling essential chromosome functions, including gene regulation, and this process has been linked with cancer development and pr...
2022-05-04 | MTBLS682 | MetaboLights
TranscriptomicsTranscription profiling of embryonic stem cells from wild type and histone deacetylase 1 (HDAC1) knock out mice to identify putative HDAC1 target genes.
Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5583 | biostudies-arrayexpress
TranscriptomicsSelective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition
Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Previous studies have shown that a reduction on histone deacetylase (HDAC) activity results on the enhancement of ...
ORGANISM(S): Mus musculus 
2010-09-17 | E-GEOD-17731 | biostudies-arrayexpress
TranscriptomicsA Multi-loop, Double-cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors
Implementation of a complex design for a microarray experiment on resistance mechanisms of histone deacetylase inhibitors (HDACI). To improve our understanding of the underlying mechanism of HDACI resistance in prostate cancer cells, we designed a novel ‘‘multiple-loop, double-cube’’ cDNA microarray...
ORGANISM(S): Homo sapiens 
2011-12-17 | E-GEOD-34452 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma.
Embryonal rhabdomyosarcoma (ERMS) is the most common soft tissue cancer in children and is characterized by myogenic differentiation arrest. The prognosis of patients with relapsed or metastatic disease remains poor. ERMS genomes show few recurrent mutations, suggesting that other molecular mechani...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-74970 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet-repeat disorders characterized by movement deficits and cognitive dysfunction. Although the mechanisms contributing to the gene expression deficits remain unknown, therapeutic ...
ORGANISM(S): Mus musculus 
2010-12-27 | E-GEOD-26317 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and mutant axel-4 Arabidopsis seedlings
A mutant screen was conducted in Arabidopsis that was based on deregulated expression of auxin-responsive transgenes. Two different tightly regulated (i.e., very low expression in the absence of auxin treatment and very high expression after exogenous auxin treatment) auxin-responsive promoters were...
ORGANISM(S): Arabidopsis thaliana 
2007-05-04 | E-SMDB-4012 | biostudies-arrayexpress
Transcriptomicsmutant axel-4 seedlings
A mutant screen was conducted in Arabidopsis that was based on deregulated expression of auxin-responsive transgenes. Two different tightly regulated (i.e., very low expression in the absence of auxin treatment and very high expression after exogenous auxin treatment) auxin-responsive promoters were...
ORGANISM(S): Arabidopsis thaliana 
2007-08-09 | E-GEOD-7587 | biostudies-arrayexpress
Transcriptomicsnuclear run-on sequencing analysis of histone deacetylase inhibition
nuclear run-on sequencing analysis of histone deacetylase inhibition
ORGANISM(S): Homo sapiens 
2012-11-30 | E-MTAB-668 | biostudies-arrayexpress
ProteomicsDevelopment of a high-throughput (10 minute microflow gradient) platform for quantitation of histone modifications on a new QTOF instrument
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms. The 5 histone proteins (H1, H2A, H2B, H3, and H4) are extensively modified, with over 75 distinct modification types spanning more than 200 sites. Despite strong advances in mass spectrom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-06 | MSV000094696 | MassIVE
Sort   by:  
 Page size