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TranscriptomicsA Multi-loop, Double-cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors
Implementation of a complex design for a microarray experiment on resistance mechanisms of histone deacetylase inhibitors (HDACI). To improve our understanding of the underlying mechanism of HDACI resistance in prostate cancer cells, we designed a novel ‘‘multiple-loop, double-cube’’ cDNA microarray...
ORGANISM(S): Homo sapiens 
2011-12-17 | E-GEOD-34452 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma.
Embryonal rhabdomyosarcoma (ERMS) is the most common soft tissue cancer in children and is characterized by myogenic differentiation arrest. The prognosis of patients with relapsed or metastatic disease remains poor. ERMS genomes show few recurrent mutations, suggesting that other molecular mechani...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-74970 | biostudies-arrayexpress
GenomicsHistone deacetylase inhibitors in alveolar rhabdomyosarcoma
Histone deacetylase inhibitors in alveolar rhabdomyosarcoma
PRJNA475783 | ENA
Transcriptomicsnuclear run-on sequencing analysis of histone deacetylase inhibition
nuclear run-on sequencing analysis of histone deacetylase inhibition
ORGANISM(S): Homo sapiens 
2012-11-30 | E-MTAB-668 | biostudies-arrayexpress
TranscriptomicsSelective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition
Histone acetylation and other modifications of the chromatin are important regulators of gene expression and, consequently, may contribute to drug-induced behaviors and neuroplasticity. Previous studies have shown that a reduction on histone deacetylase (HDAC) activity results on the enhancement of ...
ORGANISM(S): Mus musculus 
2010-09-17 | E-GEOD-17731 | biostudies-arrayexpress
MetabolomicsMolecular changes in cancer cells exposed to an HDAC inhibitor: A metabolomics approach
Histone deacetylase (HDAC) inhibitors are part of a new generation of epigenetic drugs for cancer treatment. It is known that histone acetylation plays a key role in controlling essential chromosome functions, including gene regulation, and this process has been linked with cancer development and pr...
2022-05-04 | MTBLS682 | MetaboLights
TranscriptomicsTranscription profiling of wild type and mutant axel-4 Arabidopsis seedlings
A mutant screen was conducted in Arabidopsis that was based on deregulated expression of auxin-responsive transgenes. Two different tightly regulated (i.e., very low expression in the absence of auxin treatment and very high expression after exogenous auxin treatment) auxin-responsive promoters were...
ORGANISM(S): Arabidopsis thaliana 
2007-05-04 | E-SMDB-4012 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to histone deacetylase inhibitors
Histone deacetylase inhibitors are a class of drug which rapidly induce hyperacetylation of histone proteins. Here, we aimed to study the association between HDACi-induced histone acetylation and changes in gene expression. To study the early responses to HDACi treatment we treated cells with three ...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-65297 | biostudies-arrayexpress
Transcriptomicsmutant axel-4 seedlings
A mutant screen was conducted in Arabidopsis that was based on deregulated expression of auxin-responsive transgenes. Two different tightly regulated (i.e., very low expression in the absence of auxin treatment and very high expression after exogenous auxin treatment) auxin-responsive promoters were...
ORGANISM(S): Arabidopsis thaliana 
2007-08-09 | E-GEOD-7587 | biostudies-arrayexpress
GenomicsDetermine the effects of Hdac3 deletion on H3K27ac profiles in murine chondrocytes[ChIP-Seq]
Histone deacetylase inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, these drugs inhibit multiple Hdacs and have detrimental effects on the pre- and post-natal skeleton. To better understand how Hdac inhibitors affect the skeleton, we focus...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-75547 | biostudies-arrayexpress
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