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GenomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [GSKJ4_ChIP-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we chemically inhibited the H3K27me3 demethylase JMJD3 using the GSKJ4 inhibitor and assayed for genome-wide changes in H3K27me3 and JMJD3 enri...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56693 | biostudies-arrayexpress
TranscriptomicsGenome-wide studies of histone Me2 SWIRM and polyamine oxidase domain homologues of mammalian LSD1
In order to gain a more global view of the activity of histone demethylases we report here studies of the two fission yeast SWIRM and polyamine oxidase domain homologues of mammalian LSD1. Consistent with previous work (Nicolas et al., 2006) we find that the two S. pombe proteins, which we name Swm...
ORGANISM(S): Schizosaccharomyces pombe 
2010-05-27 | E-GEOD-6224 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [GSKJ4_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we chemically inhibited the H3K27me3 demethylase JMJD3 using the GSKJ4 inhibitor and assayed for genome-wide changes in H3K27me3 and JMJD3 enri...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56691 | biostudies-arrayexpress
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [short_hairpins_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide expression ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56689 | biostudies-arrayexpress
GenomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [shJMJD3_ChIP-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide changes in ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56692 | biostudies-arrayexpress
GenomicsGlioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation
Tumor-initiating cells are a subpopulation of cells that have self-renewal capacity to regenerate a tumor. Here, we identify stem cell-like chromatin features in human glioblastoma initiating cells (GICs) and link them to a loss of the repressive histone H3 lysine 9 trimethylation (H3K9me3) mark. In...
EGAS00001003750 | EGA
TranscriptomicsTranscription profiling of pituitary glands from wild type and LSD1 knock-out mice
Precise control of transcriptional programs underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies, but how specific members of histone modification enzyme families such as histone methyltransferases and demethylases are utili...
ORGANISM(S): Mus musculus 
2007-02-13 | E-TABM-223 | biostudies-arrayexpress
TranscriptomicsThe S. cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2
Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approac...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-7627 | biostudies-arrayexpress
GenomicsKDM6 Histone Demethylases Tune Pancreatic Cancer Plasticity
KDM6 Histone Demethylases Tune Pancreatic Cancer Plasticity
PRJNA835430 | ENA
GenomicsKDM6 Histone Demethylases Tune Pancreatic Cancer Plasticity
KDM6 Histone Demethylases Tune Pancreatic Cancer Plasticity
PRJNA1504960 | ENA
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