Histone epi-proteome

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Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania (1)

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Histone Modification Analysis of Oligodendroglioma and Astrocytoma Brain Cancer Samples

WHO classification for tumors of the central nervous system strongly endorses molecular tests for the precise diagnosis of diffuse gliomas. While alterations in the DNA methylation status of gliomas are already well documented and used in specialised clinical centers to distinguish between brain tum...

ORGANISM(S): Homo sapiens (Human)

2020-01-17 | PXD015151 | Pride

EpiProfile 2.0: a proteomics tool to quantify histone modifications by mass spectrometry

The histone LC-MS/MS data analysis is challenging due to the large number and variety of isobaric histone peptides, and the high dynamic range of histone peptide abundances. We introduce EpiProfile 2.0 to quantify histone post-translational modifications from mass spectrometry data, in which fragmen...

ORGANISM(S): Homo sapiens (Human)

2018-05-29 | PXD004166 | Pride

Proteomics Post-translational modification Mass spectrometry Histone Quantification

Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Not available

S-EPMC5716079 | biostudies-literature

Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus (HSV-1) Infection

Herpes simplex virus (HSV-1) lytic infection results in global changes to the host cell proteome and the proteins associated with host chromatin. We present a system level characterization of proteome dynamics during infection by performing a multi-dimensional analysis during HSV-1 lytic infection o...

ORGANISM(S): Homo sapiens (Human) Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)

2017-02-10 | PXD005467 | Pride

Post-translational modifications (ptms) Viral life cycle Chromatin dynamics Herpes simplex virus (hsv-1) infection Lytic infection Phosphoproteomics Histone modifications

Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus Type 1 (HSV-1) Infection.