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TranscriptomicsdKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing.
Transcription regulation involves enzyme-mediated changes in chromatin structure. Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2). This pathway was uncovered thr...
ORGANISM(S): Drosophila melanogaster 
2011-12-13 | E-GEOD-34390 | biostudies-arrayexpress
TranscriptomicsExpression data from 17 day old testes of wild type and UBR2-/- mice
Ubiquitylation of histones provides an important mechanism regulating chromatin remodeling and gene expression. Recent studies have revealed ubiquitin ligases involved in histone ubiquitylation, yet the responsible enzymes and the function of histone ubiquitination in spermatogenesis remain unclear....
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-18824 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Microarray Analysis of Histone H2B Ubiquitylation mutant strains of Tetrahymena thermophila
Microarray analyses were performed to compare the gene expression profiles of wild-type and several mutant strains of the ciliated protozoan Tetrahymena thermophila. Elimination of H3K4 methylation (hht2-K4Q) and knockout of either of the ubiquitylation enzymes (delta-UBC2 and delta-BRE1) affects a ...
ORGANISM(S): Tetrahymena thermophila 
2010-06-20 | E-GEOD-18743 | biostudies-arrayexpress
GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
GenomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [ChIP-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53206 | biostudies-arrayexpress
TranscriptomicsDzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation [RNA-seq]
In mouse embryonic stem cells (mES cells), ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-71882 | biostudies-arrayexpress
GenomicsH3K27me3 is not required for recruitment of Polycomb repressor complex 1 to target loci in mouse embryonic stem cells
The established hierarchical model explaining co-occupancy of Polycomb repressor complexes 1 and 2 (PRC 1 and 2) at target loci proposes that the chromodomain of the polycomb protein, a core PRC1 subunit, recognises the H3K27me3 histone modification catalysed by PRC2. We used chromatin immunoprecipi...
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-23716 | biostudies-arrayexpress
GenomicsDzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation [ChIP-seq]
In mouse embryonic stem cells (mES cells), ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-71883 | biostudies-arrayexpress
UnknownFunctional crosstalk between histone H2B ubiquitylation and H2A modifications and variants.
Not available
S-EPMC5895630 | biostudies-literature
UnknownNovel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A.
Not available
S-EPMC2897545 | biostudies-literature
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