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GenomicsSimultaneous identification of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing
Simultaneous identification of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing
PRJNA997991 | ENA
OtherSimultaneous identification of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing
The Human Leukocyte Antigen (HLA) locus associates with a variety of complex diseases, particularly autoimmune and inflammatory conditions. The HLA-DR15 haplotype, for example, confers the major risk for developing Multiple Sclerosis in Caucasians, pinpointing important role in the etiology of this ...
ORGANISM(S): Homo sapiens 
2023-08-15 | GSE238121 | GEO
UnknownHLA class II locus and susceptibility to podoconiosis.
Not available
S-EPMC3350841 | biostudies-literature
ProteomicsImmunopeptidomics of colorectal cancer organoids
Background: Patient derived organoids (PDOs) can be established from colorectal cancers as in vitro models to interrogate cancer biology and its clinical relevance. We applied mass spectrometry (MS) immunopeptidomics to investigate neoantigen presentation and whether this can be augmented through in...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD014017 | Pride
Organoids Colorectal cancer Mass spectrometry Immunopeptidomics 
TranscriptomicsGenome-wide profiling characterizes CRCs with genetic instability and specific routes to HLA class I loss and immunoescape
We compared the expression of genes related to inflammatory cytotoxic functions between MSI and MSS (HLA class I negative and positive) gastrointestinal adenocarcinomas (GIACs), seeking evidence of differences in inflammatory mediators and cytotoxic T-cell responses. Twenty-two GIACs were divided in...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-27544 | biostudies-arrayexpress
UnknownHLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Not available
S-EPMC4702958 | biostudies-literature
UnknownSimultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing.
Not available
S-EPMC10484099 | biostudies-literature
UnknownReplication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups.
Not available
S-EPMC7870958 | biostudies-literature
UnknownEBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes.
Not available
S-EPMC8370649 | biostudies-literature
UnknownConfirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.
Not available
S-EPMC2779837 | biostudies-literature
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