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Genomics5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging [5hmC Capture and Seq]
DNA methylation dynamics influence brain function and are altered in neurological disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base derived from 5-methylcytosine (5mC) accounts for ~40% of modified cytosine in brain, and has been implicated in DNA methylation-related plasticity. Here we map 5-h...
ORGANISM(S): Mus musculus 
2011-10-30 | E-GEOD-32050 | biostudies-arrayexpress
GenomicsIntegrating 5 Hydroxymethylcytosine into the Epigenetic Landscape of Human Embryonic Stem Cells
Covalent modification of DNA distinguishes cellular identities and is crucial for regulating the pluripotency and differentiation of embryonic stem (ES) cells. The recent demonstration that 5-methylcytosine (5-mC) may be further modified to 5-hydroxymethylcytosine (5-hmC) in ES cells has revealed a ...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-30173 | biostudies-arrayexpress
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
GenomicsLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for varius biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family of DNA hydroxylases. Here we report that "loss of 5-hmC&...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-38231 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of two mesothelioma cell lines (MPP89 and REN), and of HMC-TERT non tumoral mesothelial cells
miRNA profile analysis of two mesothelioma cell lines (MPP89 and REN), and of HMC-TERT non tumoral mesothelial cells
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1699 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesothelioma cells MPP-89 REN compared to mesothelial cells HMC-TERT
gene expression profile of mesothelioma cells (MPP-89; REN) compared to mesothelial cells (HMC-TERT)
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1701 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesothelioma cells (MPP-89, REN) compared to mesothelial cells (HMC-TERT)
gene expression profiles of mesothelioma cells (MPP-89, REN) compared to mesothelial cells (HMC-TERT)
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1700 | biostudies-arrayexpress
GenomicsSelective chemical labeling reveals intragenic enrichment of 5-hydroxymethylcytosine in mouse cerebellum
5-Methylcytosine (5-mC) is an important DNA modification found in eukaryotes that impacts gene regulation and disease pathogenesis. Recently, 5-hydroxymethylcytosine (5-hmC), another form of DNA modification, has been identified in substantial amounts in certain mammalian cell types; however, its ro...
ORGANISM(S): Mus musculus 
2010-12-12 | E-GEOD-25398 | biostudies-arrayexpress
GenomicsGenome-Wide Mapping of 5-mC and 5-hmC in severely Preeclamptic Placentas.
Preeclampsia (PE) is a major contributor of maternal mortality with uncertain etiology. Recent studies suggested that epigenetic modifications, including DNA methylation, play a vital role in the development of PE. In this study, we have mapped genome-wide distribution of 5-methylcytosin (5-mC) and ...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-63743 | biostudies-arrayexpress
GenomicsGenome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer
Background: 5-hydroxymethylcytosine (5-hmC) is a recently discovered epigenetic modification that is altered in cancers. Genome wide assays for 5-hmC determination are needed as many of the techniques commonly used to assay 5-methylcytosine (5-mC), including conventional methyl-sensitive restriction...
ORGANISM(S): Homo sapiens 
2013-07-30 | E-GEOD-42723 | biostudies-arrayexpress
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