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ProteomicsProbing condensate microenvironments and functions with a micropeptide “killswitch”
Biomolecular condensates are implicated in many cellular processes, and are thought to create subcellular microenvironments that regulate specific biochemical activities. For example, in vitro experiments suggest that condensates enable non-stoichiometric enrichment of small molecules within condens...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD058854 | Pride
Condensates 
GenomicsHistone deacetylation at coding sequences adjusts transcription kinetics during Candida albicans morphogenesis [ChIP-seq]
The dataset contains ChIP-Seq data of the Set3 and Hos2 proteins in Candida albicans, assayed in two morphological phases (yeast and hypha). The Set3 and Hos2 proteins in the respective strains carry 9myc epitopes and ChIP was performed with an anti-myc antibody. Included samples are the following: ...
ORGANISM(S): Candida albicans 
2013-01-01 | E-GEOD-38425 | biostudies-arrayexpress
TranscriptomicsSimultaneous RNA-seq of bone marrow derived dendritic cells from Mus Musculus C57BL/6 cocultured with Candida albicans strain SC5314 over a 2 hour infection time course
Bone marrow derived dendritic cells from Mus Musculus were cocultured with Candida albicans at a target ratio of 1:1 between 0 and 120 min and samples were collected every 30 minutes.
ORGANISM(S): Mus Musculus 
2013-06-18 | E-MTAB-595 | biostudies-arrayexpress
TranscriptomicsMaster Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
The master transcription factors Oct4, Sox2 and Nanog bind enhancer elements and recruit the Mediator co-activator to activate much of the gene expression program of embryonic stem cells (ESCs). We report here that these ESC master transcription factors and Mediator form M-bM-^@M-^\super-enhancersM...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-42474 | biostudies-arrayexpress
GenomicsConvergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
Super-enhancers and stretch enhancers (SEs) drive expression of genes that play prominent roles in normal and disease cells, but the functional importance of these clustered enhancer elements is poorly understood, so it is not clear why genes key to cell identity have evolved regulation by such elem...
ORGANISM(S): Mus musculus 
2014-12-15 | E-GEOD-64188 | biostudies-arrayexpress
TranscriptomicsLong-range chromatin interactions in mouse embryonic stem cells identified by ChIA-PET [ChIA-PET]
The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of cell identity genes and repression of genes encoding lineage-specifying developmental regulators. Here we use large ESC cohesin ChIA-PET datasets and other genomic data to identify the local chromosomal struc...
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-57911 | biostudies-arrayexpress
TranscriptomicsRecurrent somatic mutations in POLR2A define a distinct subset of meningiomas [array]
RNA polymerase II mediates the transcription of all protein-coding genes in eukaryotic cells, a process that is fundamental to life. Genomic mutations in this enzyme have not been previously linked to any pathology in humans, a testament to its indispensable role in cell biology. Based on a combinat...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-84263 | biostudies-arrayexpress
TranscriptomicsRecurrent somatic mutations in POLR2A define a distinct subset of meningiomas [RNA-seq]
RNA polymerase II mediates the transcription of all protein-coding genes in eukaryotic cells, a process that is fundamental to life. Genomic mutations in this enzyme have not been previously linked to any pathology in humans, a testament to its indispensable role in cell biology. Based on a combinat...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-85133 | biostudies-arrayexpress
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