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TranscriptomicsGene expression signatures of HO-1 in BeWo cells
Heme Oxygenase-1 (HO-1) is expressed in many cancers and influences the growth, survivall and metastasis of tumors, however, the molecular mechanisms remains largely unknown. To identify a common mechanism of action of HO-1 in cancer, we studied the global effect of HO-1 on the transcriptome of mul...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-20404 | biostudies-arrayexpress
GenomicsAscl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts [ChIP-seq]
Wnt signals control three functions of intestinal crypts: maintenance of Lgr5 stem cells, proliferation of transit-amplifying daughters and formation of Paneth cells. Here, we study how the Wnt effector β-catenin/Tcf4 cooperates with the Wnt-activated transcription factor Ascl2 to control a stem ce...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-84456 | biostudies-arrayexpress
GenomicsHO-1 attenuates testicular ischemia/reperfusion injury through activating the phosphorylated c-Jun-miR-221/222-TOX pathway [miRNA]
Heme oxygenase(HO-1) has been shown to protect against I/R injury, but its effects on testicular I/R is very limited. Therefore, this study aims to investigate the effects of HO-1 on testicular I/R and the underlying mechanism.Knockout of HO-1 rats by TALEN technique.Immunofluorescence and immunohis...
ORGANISM(S): Rattus norvegicus 
2024-02-14 | GSE236536 | GEO
GenomicsHO-1 attenuates testicular ischemia/reperfusion injury through activating the phosphorylated c-Jun-miR-221/222-TOX pathway [lncRNA+circRNA]
Heme oxygenase(HO-1) has been shown to protect against I/R injury, but its effects on testicular I/R is very limited. Therefore, this study aims to investigate the effects of HO-1 on testicular I/R and the underlying mechanism.Knockout of HO-1 rats by TALEN technique.Immunofluorescence and immunohis...
ORGANISM(S): Rattus norvegicus 
2024-02-14 | GSE237563 | GEO
UnknownCLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells.
Not available
S-EPMC12445528 | biostudies-literature
GenomicsThe balance between R-loop levels and RNAPII occupancy dictates Transcription-Replication Conflict occurrence
The balance between R-loop levels and RNAPII occupancy dictates Transcription-Replication Conflict occurrence
PRJNA1456433 | ENA
TranscriptomicsHO-1 modulates the expression of genes involved in inflammation, angiogenesis, proliferation, apoptosis and cell adhesion in human lung cancer cells.
The enzymatic activity of HO-1 results in decreased oxidative stress, attenuated inflammatory response, and very often in a lower rate of apoptosis. This is due to removal of heme, a potent prooxidant and proinflammatory agent, but mainly because of generation of biologically active products such as...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22030 | biostudies-arrayexpress
UnknownThermodynamics of boroxine formation from the aliphatic boronic acid monomers R-B(OH)2 (R = H, H3C, H2N, HO, and F): a computational investigation.
Not available
S-EPMC3154741 | biostudies-literature
ProteomicsProteome analysis of Mel426 melanoma cells with R2PD1 treatment
A label-free quantification experiment was performed to study the effect of R2PD1 chimeric protein treatment on the cellular proteome of Mel426 human melanoma cells. Peptides were separated by online reverse phase liquid chromatography and measured in an Exploris 480 Orbitrap mass spectrometer. Mas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-16 | MSV000091500 | MassIVE
UnknownOxidation Kinetics of Nanocrystalline Hexagonal RMn1-xTixO3 (R = Ho, Dy).
Not available
S-EPMC10510046 | biostudies-literature
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