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TranscriptomicsTranscription profiling of primary fibroblasts from a family with autosomal recessive Hutchinson-Gilford Progeria Syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina. By studying a family with homozygous LMNA mutation (K542N), we s...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-MEXP-3097 | biostudies-arrayexpress
TranscriptomicsCD24 targets
Gene expression were identified with or without CD24 gene silencing in Du145 cells. RNA isolated from 5 independent cultures of Scramble control, 3 cultures of CD24-ShRNA1 and 2 cultures of CD24-ShRNA2 were tested using Affimatrx Human U133 Plus 2.0 microarrays.
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-46708 | biostudies-arrayexpress
TranscriptomicsGenome wide mapping of histone acetyltransferase MOF binding in murine ES cells.
We report the application of Affy based microarray technology for profiling of gene expression in mouse embryonic stem cells with or without histone acetytransferase MOF. We find that Mof regulates a wide range of genes in mouse ESCs including those important for ESC pluripotency and ESC differentia...
ORGANISM(S): Mus musculus 
2012-04-11 | E-GEOD-37109 | biostudies-arrayexpress
TranscriptomicsCited-1 deficiency suppresses intestinal tumorigenesis through the repression of the Wnt pathway- evidence for the just right model of Wnt mediated tumorigenesis
Comparison of the expression profiles of the following genetically altered murine intestinal epithelium: AhCre wildtype, AhCre Apc floxed, AhCre Cited1 null and Ahcre Apcflx/Cited1 null.
ORGANISM(S): Mus musculus 
2012-05-05 | E-MEXP-3202 | biostudies-arrayexpress
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