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TranscriptomicsHistoplasma capsulatum induces a Type I interferon response that contributes to pathogenesis in mice
To identify signaling pathways that are induced by macrophages infected with Histoplasma capsulatum, we examined the whole genome expression profile of murine bone marrow derived macrophages infected with conidia, the natural infectious particle of Histoplasma. Conidia induced the expression of sign...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-20022 | biostudies-arrayexpress
TranscriptomicsCD103+ Conventional Dendritic Cells are Critical for TLR-dependent Host Defense against an Endemic Fungal Pathogen
Innate immune cells shape the host response to microbial pathogens. Here we studied the role of TLR7/9 in dendritic cell (DC) responses to Histoplasma capsulatum, an intracellular fungal pathogen of humans. Whereas macrophages succumbed to Histoplasma infection, TLR7/9 were critical for DCs to produ...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-70505 | biostudies-arrayexpress
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