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TranscriptomicsComparative profiling in 13 muscle disease groups
Summary: Genetic disorders of muscle cause muscular dystrophy, and are some of the most common inborn errors of metabolism. Muscle also rapidly remodels in response to training and innervation. Muscle weakness and wasting is important in such conditions as aging, critical care medicine, space flig...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-GEOD-3307 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of human skeletal muscle samples from metabolic syndrome patients following defined exercise (STRRIDE study)
STRRIDE is an exercise intervention study of different doses and intensities in overweight women and men with the metabolic syndrome. We profiled biopsies from 3 female and 3 male STRRIDE subjects in the “high” exercise group (2,200 kCal/wk). Muscle biopsies were profiled at entry (0h), and afte...
ORGANISM(S): Homo sapiens 
2007-08-02 | E-GEOD-1295 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung treated with dexamethasone, retanoic acid vs. control to understand the molecular basis for the Dex indiced inhibition of the formation of the alveoli and the ability of ATRA to prevent the inhibition of septation
It has been shown that dexamethasone (Dex) impairs the normal lung septation that occurs in the early postnatal period. Treatment with retinoic acid (ATRA) abrogates the effects of Dex. To understand the molecular basis for the Dex indiced inhibition of the formation of the alveoli and the ability o...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-484 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
The transcription factor MyoD can coax na?e fibroblasts or otherwise committed cells to adopt the skeletal muscle phenotype by activating the muscle gene expression program. Activation of muscle gene expression occurs in quantal steps with not all the target genes of MyoD being activated at the same...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6487 | biostudies-arrayexpress
UnknownAccelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, and efficient neoadjuvant treatment for muscle-invasive bladder cancer: results of a multicenter phase II study with molecular correlates of response and toxicity.
Not available
S-EPMC4050203 | biostudies-literature
TranscriptomicsTranscription profiling of 16-week-old mdx mouse muscles to characterize transcriptional changes induced by dystrophin deficiency.
Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human acute quadriplegic myopathy patients
AQM shows acute muscle wasting and weakness. Key aspects of AQM include muscle atrophy and myofilament loss. Gene expression profiling, using muscle biopsies from AQM, neurogenic atrophy and normal controls, showed that both myogenic and neurogenic atrophy share induction of myofiber-specific ubiqui...
ORGANISM(S): Homo sapiens 
2007-07-21 | E-GEOD-1017 | biostudies-arrayexpress
TranscriptomicsResponse of multiple genes to a chronic dose of corticosteroids in rat muscles
Synthetic glucocorticoids are used therapeutically for a variety of conditions. Both the efficacy and toxicity of corticosteroids arise from their pharmacologically exaggerated effects on target and non-target tissues. For example, beneficial effects deriving from inhibition of the immune system are...
ORGANISM(S): Rattus norvegicus 
2006-06-19 | E-GEOD-5101 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Facioscapulohumeral muscular dystrophy (FSHD) muscle profiles
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder linked to contractions of the D4Z4 repeat array in the subtelomeric region of chromosome 4q. By comparing genome-wide gene expression data from muscle biopsies of patients with FSHD to those of 11 other neuromuscular dis...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9397 | biostudies-arrayexpress
UnknownThree-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial.
Not available
S-EPMC6286164 | biostudies-literature
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