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ModelsODea2007 - A homeostatic model of IκB metabolism to control constitutive NF-κB activity
Insert Citation Questions concerning the paper should be addressed to the corresponding author. Alexander Hoffmann (ahoffmann@ucsd.edu) The original model was written and simulated within MathWorks MatLab 2006a using the ode15s (stiff/NDF) solver. It is highly recommended...
2019-08-27 | MODEL1908270002 | BioModels
ProteomicsStimulus-specific Immune Modulation by SARS-CoV-2 Nucleocapsid Correlates with Severe COVID-19
A significant proportion of patients with COVID-19 disease, caused by SARS-CoV-2, develop acute respiratory distress syndrome characterized by pro-inflammatory cytokine secretion and dampened IFN-mediated antiviral response. To uncover the mechanisms by which SARS-CoV-2 drives this dysregulation, we...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2026-06-25 | PXD067631 | Pride
Sars-cov-2 Macrophages Nf-kb pathways Nucleocapsid (n) Pro-inflammatory responses 
ModelsODea2007_IkappaB
O'Dea, E.L., Barken, D., Peralta, R.Q., Tran K.T., Werner, S.L., Kearns, J.D., Levchenko, A., Hoffmann, A. A homeostatic model of IkB metabolism to control constitutive activity. Molecular Systems Biology, 3:111, pp. 1-7. 2007 Questions concerning the paper should be addressed to the corresp...
2024-09-02 | BIOMD0000000147 | BioModels
TranscriptomicsDifferential repression of TLR responses by PPARg and LXRs
Transrepression mediated by PPARg and LXRs agonists (GW7845 and GW3965) in primary macrophages stimulated with LPS or poly I:C. Thioglycollate-elicited macrophages were isolated from mice by peritoneal lavage 3 days following peritoneal injection of 2.5 ml 3% thioglycollate (DIFCO). Cells were plate...
ORGANISM(S): Mus musculus 
2006-12-15 | GSE6346 | GEO
UnknownAtezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): a multicentre, randomised, open-label, phase 3 trial.
Not available
S-EPMC11017728 | biostudies-literature
UnknownLysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells.
Not available
S-EPMC9267536 | biostudies-literature
UnknownAggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.
Not available
S-EPMC6355082 | biostudies-literature
ModelsHoffmann2002_WT_IkBNFkB_Signaling
This model corresponds to the IkB-NFkB signaling in wild type cells and reproduces the dynamics of the species as depicted in Figure 2 F of the paper. The authors mention that the simulation is carried out in three phases, where the steady state values of the species in one phase are fed to the suc...
2024-09-02 | BIOMD0000000140 | BioModels
ModelsHoffmann2002_KnockOut_IkBNFkB_Signaling
The model corresponds to the knock out model of beta-/-, epsilon -/- and reproduces the upper panel in Fig 2C. In order to reproduce the other knock out models the transcription rate of the species that are not present must be set to zero and the rate of the one that is present must be set as seven ...
2024-09-02 | BIOMD0000000139 | BioModels
ModelsWerner2005_IkappaB_kinase
This is the model described in the article: Stimulus specificity of gene expression programs determined by temporal control of IKK activity. by Werner SL, Barken D, Hoffmann A. Science. 2005 Sep 16;309(5742):1857-61; PMID: 16166517 , DOI= 10.1126/...
2005-01-01 | MODEL1008110000 | BioModels
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