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GenomicsIdh1-R132H mutation increases murine hematopoietic progenitors and alters epigenetics.
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequent in human glioblastomas1 and cytogenetically normal acute myeloid leukemias (AML)2. These alterations are gain-of-function mutations in that they drive the synthesis of the M-bM-^@M-^\oncometaboliteM-bM-^@M-^] R-2-hy...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-38687 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon Caco-2 cells treated with hydroxytyrosol (HTy) and hydroxytyrosyl ethyl ether (HTy-Et)
The anticarcinogenic activity of hydroxytyrosyl ethyl ether (HTy-Et) compared to its precursor hydroxytyrosol (HTy) has been studied in human Caco-2 colon adenocarcinoma cells. Changes in global gene expression in Caco-2 cells exposed to HTy and HTy-Et for 24 h were evaluated using Affymetrix array....
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-38833 | biostudies-arrayexpress
TranscriptomicsRegulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein
The EwingM-bM-^@M-^Ys sarcoma protein EWS belongs to the TET family (FUS/TLS, EWS, TAF15) of RNA and DNA binding proteins, implicated in DNA transcription, pre-mRNA splicing and maintenance of genomic integrity. Translocations of these genes are characteristic of particular neoplasias, including Ewi...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-48065 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HIV-1 latently infected memory CD4+ T cells
Suppressive HAART does not eradicate HIV-1 and viral DNA persists as a stably integrated form in the absence of viral particle production. As a consequence, latent reservoirs are refractory to antiretroviral drugs and invisible to immune surveillance. The largest latent reservoir consists of resting...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-GEOD-40550 | biostudies-arrayexpress
TranscriptomicsListeria monocytogenes Sigma B, but not PrfA, shows strain specific contributions to growth under salt stress, and prolongated lag phase of a sigB null mutant across strains
Listeria monocytogenes is well known to have the ability to survive and grow under a variety of stress conditions. The ability to survive and grow under osmotic stress conditions in particular appears to be important for both growth in certain foods and food associated environments as well as for ho...
ORGANISM(S): Listeria monocytogenes 
2013-07-20 | E-GEOD-49056 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseudomonas putida KT2440 and mutant PP4959 in the stationary phase of growth in LB
Effect of the inactivation of locus PP4959 upon gene expression of Pseudomonas putida KT2440 in the stationary phase of growth in rich medium LB. This locus encodes the unique dual GGDEF/EAL domains response regulator in KT2440. To identify those genes with altered expression, cells were cultivated ...
ORGANISM(S): Pseudomonas putida 
2010-06-01 | E-MEXP-2486 | biostudies-arrayexpress
GenomicsWhole-genome nucleosome mapping in meiotic diploid S. cerevisiae
We determined nucleosome positions throughout the genome in diploid S. cerevisiae undergoing early stages of synchronous meiosis. This study sought to assess if systematic reorganization of nucleosomes occurs during meiotic prophase at or near sites of DNA double strand break formation. Six samples ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse aorta (whole or regions) from mice of different embryonic ages
In order to identify novel regulators of haematopoietic stem cell emergence in the mouse embryonic AGM region, 3 different types of gene expression comparisons were performed. In the first one, whole dorsal aortas from embryonic day (E) 11 embryos and E9 embryos were dissected, tissues from each tim...
ORGANISM(S): Mus musculus 
2009-06-06 | E-TABM-659 | biostudies-arrayexpress
TranscriptomicsRNA-seq study of the response of the diatom Leptocylindrus aporus to changing temperature conditions.
The goal of the experiment was to compare the behavior and responses of a warm water diatom species in three different temperatures, low, intermediate and high, with the final aim of investigating possible intraspecific variability and better understanding the physiological plasticity and/or adaptat...
ORGANISM(S): Leptocylindrus aporus 
2019-12-21 | E-MTAB-8596 | biostudies-arrayexpress
TranscriptomicsLack of the pif1 helicase enhances zinc tolerance in S. cerevisiae
The Saccharomyces cerevisiae gene PIF1 encodes a conserved eukaryotic DNA helicase required for both mitochondrial and nuclear DNA integrity. Our previous work revealed that a pif1D strain is tolerant to zinc overload. We demonstrate here that this effect is independent of the Pif1 helicase activity...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-31 | E-GEOD-18411 | biostudies-arrayexpress
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