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MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
MetabolomicsRNA virus-induced metabolic reprogramming in a bloom-forming, marine diatom
• Diatoms are a widespread group of phytoplankton that disproportionately influence the global carbon cycle through substantial contributions to primary production and carbon export in the ocean. Marine viruses are major drivers of host metabolic reprogramming and mortality and it is increasingly cl...
2026-10-09 | MTBLS15467 | MetaboLights
MetabolomicsA Randomized Controlled Trial of Shengji Ointment Combined with Bromelain in Promoting Healing of Tendon-Exposed Diabetic Foot Wounds: Metabolomics Profiling Analysis

Background: Diabetic foot tendon exposures are prone to infection, necrosis, and prolonged treatment cycles, not only hindering wound healing but potentially leading to amputation and life-threatening complications. Shengji ointment combined with bromelain has demonstrated preliminary efficacy i...

2025-07-14 | MTBLS12713 | MetaboLights
GenomicsStudy on the Cloning, Expression, and Antimicrobial Activity of the Holin Gene from Klebsiella pneumoniae Bacteriophage
Study on the Cloning, Expression, and Antimicrobial Activity of the Holin Gene from Klebsiella pneumoniae Bacteriophage
PRJEB107076 | ENA
UnknownA dimeric holin/antiholin complex controls lysis by phage T4.
Not available
S-EPMC11413866 | biostudies-literature
MetabolomicsMultiomic analysis reveals a role of Fusobacterium periodonticum in colorectal tumorigenesis by decanoic acid promoting neutrophil chemotaxis
Gut microbiota dysbiosis and immune dysregulation are closely linked to colorectal cancer development. Identifying mechanistic connections among specific microbial species, metabolites, and immune responses may reveal novel insights into its pathogenesis. Here, employing metagenomic, metabolomic, an...
2026-05-20 | MTBLS14505 | MetaboLights
UnknownBiological Characterization and Evolution of Bacteriophage T7-△holin During the Serial Passage Process.
Not available
S-EPMC8365609 | biostudies-literature
UnknownSecretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE.
Not available
S-EPMC3369941 | biostudies-literature
UnknownHolin-Dependent Secretion of the Large Clostridial Toxin TpeL by Clostridium perfringens.
Not available
S-EPMC8088506 | biostudies-literature
UnknownA Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridiumsordellii.
Not available
S-EPMC8878733 | biostudies-literature
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