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TranscriptomicsMammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Progression to malignancy requires cells to overcome senescence and switch to an immortal phenotype. Thus, exploring the genetic and epigenetic changes that occur during senescence/immortalization may help elucidate crucial events that lead to cell transformation. In the present study, we have globa...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-39034 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by the human aristolochic acid I in renal and hepatic tissue of mice
Aristolochic acid (AA) is the causative agent of urothelial tumours associated with aristolochic acid nephropathy and is also implicated in the development of Balkan endemic nephropathy-associated urothelial tumours. These tumours contain AA-characteristic TP53 mutations. We examined gene expression...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-18246 | biostudies-arrayexpress
TranscriptomicsThe codon 72 polymorphism of p53 regulates interactions with NF-κB and transactivation of genes involoved in immunity and inflamation
A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either proline(P72) or arginine(R72). These two variants might possess altered biological function which influences p53’s transcriptional, senescence and apoptotic functions. We found that P72 has increased apoptosis when com...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26851 | biostudies-arrayexpress
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