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TranscriptomicsOncogenic potential of RAS isoforms in melanocytes
We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weak...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-6194 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WGS
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-4921 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WGS part 2
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-5590 | biostudies-arrayexpress
GenomicsIntegrative and comparative genomics identifies the tyrosine kinase FES as a key melanoma tumor supppressor: WES
An incomplete view of the (epi)genetic events that drive melanoma initiation and progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. Recent approaches that integrate human melanoma genomic and transcriptomic data pr...
ORGANISM(S): Mus musculus 
2017-05-03 | E-MTAB-4917 | biostudies-arrayexpress
UnknownExploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma.
Not available
S-EPMC6456057 | biostudies-literature
UnknownA Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma.
Not available
S-EPMC6292789 | biostudies-literature
UnknownTargeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
Not available
S-EPMC5977991 | biostudies-literature
UnknownDurable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Not available
S-EPMC7933113 | biostudies-literature
TranscriptomicsMammographic density and genetics - A study of breast biopsies in relation to mammoraphic density
Introduction Mammographic density (MD), as assessed from film screen mammograms, is determined by the relative content of adipose, connective and epithelial tissue in the female breast. In epidemiological studies, a high percentage of MD confers a four to six fold risk elevation of developing breast...
ORGANISM(S): Homo sapiens 
2010-08-13 | E-GEOD-18672 | biostudies-arrayexpress
UnknownTrans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
Not available
S-EPMC3605054 | biostudies-literature
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