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GenomicsChIPseq analyses in germinal center B cells
Germinal center B cells were isolated from human tonsil tissue and crosslinked. ChIP was performed on two distinct pools of germinal center cells, each obtained from 3-5 donors. The experiment includes two biological replicates (germinal center cell pools from different donors). ChIP was performed o...
ORGANISM(S): Homo sapiens 
2015-12-04 | E-GEOD-68349 | biostudies-arrayexpress
TranscriptomicsSmall-RNA expression in normal and malignant mature B cells
Small-RNA profiles were generated for normal mature germinal center (GC) B cells and GC-derived lymphomas. Normal and tumor samples are derived from different donors.
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56354 | biostudies-arrayexpress
TranscriptomicsmiR-28 expression in the Burkitt lymphoma cell line P3HR1
Burkitt lymphoma (BL) is a highly aggressive B cell non-Hodgkin lymphoma (B-NHL), which originates from germinal center (GC) B cells and harbors translocations deregulating the MYC oncogene. A comparative analysis of microRNAs (miRNAs) expressed in normal and malignant GC B cells identified miR-28 a...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56268 | biostudies-arrayexpress
TranscriptomicsExpression profiles of murine FOXO1+/+ and FOXO1-null GC B cells
The pathways regulating the formation of the germinal center (GC) dark- (DZ) and light- (LZ) zones are unknown. We show that FOXO1 expression is restricted to the GC DZ and is required for DZ formation, since its absence in mice leads to the complete loss of DZ gene programs and the formation of LZ-...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-69216 | biostudies-arrayexpress
TranscriptomicsA tRNA-derived microRNA modulates the DNA damage response and is downregulated in B cell lymphoma
Sequencing studies from several model systems have suggested that diverse and abundant small RNAs may derive from tRNA, but the function of these molecules remains undefined. Here we demonstrate that one such tRNA fragment, cloned from human B cells and designated CU1276, in fact possesses the func...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42989 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of pediatric T cell lymphoblastic lymphoma
miRNA profiling has been performed on primary tumor samples collected at diagnosis from pediatric patients affected by T-cell lymphoblastic lymphoma. Tumor tissue was frozen at the time of surgery. Mononucleated cells were isolated from pleural effusions upon red blood cell lysis and frozen. The ex...
ORGANISM(S): Homo sapiens 
2014-06-10 | E-GEOD-55846 | biostudies-arrayexpress
GenomicsIdentification of MLL2 regulated genes in germinal center B cells
Somatic mutations of the MLL2 methyltransferase gene represent a common genetic lesion in multiple cancer types. In diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), these mutations are highly recurrent and occur early during tumorigenesis, suggesting a central role in transformati...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-67494 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype
Among acute myeloid leukemias (AML) with normal karyotype (CN-AML), NPM1 and CEBPA mutations define WHO provisional entities accounting for ~60% of cases, but the remaining ~40% remains poorly characterized. By whole exome-sequencing (WES) of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-30442 | biostudies-arrayexpress
UnknownDecreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Not available
S-EPMC9515432 | biostudies-literature
UnknownCSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Not available
S-EPMC10165192 | biostudies-literature
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