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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsTranscription profiling by array of E. coli MG1655 strains with deletions of fis and hns in early-exponential, mid-exponential, transition-to-stationary and stationary phases
Differential expression of genes in E. coli MG1655 strains with deletions of fis and hns was assessed under early-exponential, mid-exponential, transition-to-stationary and stationary phases of growth in LB medium.
ORGANISM(S): Escherichia coli 
2010-09-01 | E-MEXP-2838 | biostudies-arrayexpress
MetabolomicsJ-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
2018-07-23 | MTBLS540 | MetaboLights
UnknownCollagen-like proteins in pathogenic E. coli strains.
Not available
S-EPMC3368898 | biostudies-literature
MetabolomicsUntargeted metabolomic analysis of human milk from healthy mothers reveals drivers of metabolite variability.
Understanding the human milk metabolome can help inform infant nutrition and health. Untargeted metabolomics was used to study breast milk from 31 healthy participants to assess the shared metabolites in milk from participants with various backgrounds and understand how different demographic, health...
2024-10-04 | MTBLS2419 | MetaboLights
UnknownPolymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.
Not available
S-EPMC3777221 | biostudies-literature
UnknownA novel mutation in RNF216 gene in a Turkish case with Gordon Holmes syndrome.
Not available
S-EPMC10169457 | biostudies-literature
UnknownTRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome.
Not available
S-EPMC6411869 | biostudies-literature
UnknownLoss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.
Not available
S-EPMC5393493 | biostudies-literature
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