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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownSteroid-responsive intracranial germinoma presenting as Holmes' tremor: importance of a tissue diagnosis.
Not available
S-EPMC4866638 | biostudies-literature
UnknownPNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum.
Not available
S-EPMC3891450 | biostudies-literature
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
GenomicsIdh1-R132H mutation increases murine hematopoietic progenitors and alters epigenetics.
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequent in human glioblastomas1 and cytogenetically normal acute myeloid leukemias (AML)2. These alterations are gain-of-function mutations in that they drive the synthesis of the M-bM-^@M-^\oncometaboliteM-bM-^@M-^] R-2-hy...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-38687 | biostudies-arrayexpress
UnknownNatural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors.
Not available
S-EPMC2546438 | biostudies-literature
UnknownHIV-1 Group M Capsid Amino Acid Variability: Implications for Sequence Quality Control of Genotypic Resistance Testing.
Not available
S-EPMC10143361 | biostudies-literature
UnknownSherlock Holmes and the Neurophysiologists: Unraveling the "Mystery" of Active Learning Success.
Not available
S-EPMC11441434 | biostudies-literature
TranscriptomicsA family of secreted pathogenesis-related proteins in Candida albicans
Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open read...
ORGANISM(S): Candida albicans 
2013-03-25 | E-GEOD-28212 | biostudies-arrayexpress
UnknownA case report: Dual-lead deep brain stimulation of the posterior subthalamic area and the thalamus was effective for Holmes tremor after unsuccessful focused ultrasound thalamotomy.
Not available
S-EPMC9798537 | biostudies-literature
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