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MetabolomicsCD36 palmitoylation regulates the lipid metabolic homeostasis

Alterations in myocardial energy substrate metabolism following myocardial infarction (MI) results in structural and functional abnormalities of the heart. The fatty acid translocase CD36 (CD36), acrucial membrane protein, plays a pivotal role in regulating fatty acid (FA) uptake and lipid homeos...

2025-06-15 | MTBLS12600 | MetaboLights
MetabolomicsHomeostasis of the biosynthetic E. coli metabolome
Metabolite concentrations vary across conditions and such metabolome changes are relevant for metabolic and gene regulation. Here, we used LC-MS/MS to explore metabolite concentration changes in Escherichia coli. We measured 101 primary metabolites in 19 experimental conditions that include v...
2022-11-02 | MTBLS4249 | MetaboLights
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathwa...

2026-02-06 | MTBLS13859 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background: Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathw...

2026-02-10 | MTBLS13881 | MetaboLights
MetabolomicsOxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Not available
ORGANISM(S): Mus musculus 
ST002280 | MetabolomicsWorkbench
MetabolomicsClostridium bolteae suppresses Enterobacteriaceae expansion and restores gut microbiome homeostasis via disrupting siderophore-mediated iron acquisition

Intestinal inflammation and the related gut microbiome dysbiosis are becoming prevalent worldwide. Overgrowth of Enterobacteriaceae exacerbates intestinal inflammation and gut microbiome dysbiosis. Enterobacteriaceae secrets siderophore to acquire iron and survive in the iron-limited gut. Therefo...

2026-01-03 | MTBLS13592 | MetaboLights
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
MetabolomicsGRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis

BACKGROUND: Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we iden...

2025-10-19 | MTBLS13178 | MetaboLights
MetabolomicsAlcohol dehydrogenase 1B is crucial for adipocyte homeostasis
Not available
ORGANISM(S): Homo sapiens 
ST002400 | MetabolomicsWorkbench
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