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UnknownNFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Not available
S-EPMC3602998 | biostudies-literature
TranscriptomicsA protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2
The association between hyper-inflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, non-transcriptional role of G...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-35197 | biostudies-arrayexpress
TranscriptomicsModeling human brain evolution using induced pluripotent stem cells: comparative analysis of neuronal development in humans and chimpanzees
Understanding evolutionary mechanisms underlying expansion and reorganization of the human brain represents an important aspect in analyzing the emergence of cognitive abilities typical of our species. Comparative analyses of neuronal phenotypes in closest living relatives (Pan troglodytes; the comm...
ORGANISM(S): Pan troglodytes 
2016-08-07 | E-GEOD-83638 | biostudies-arrayexpress
GenomicsRequired Enhancer: Matrin-3 Structure Interactions for Homeodomain Transcription Programs
Study of the POU-homeodomain transcription factor, has revealed that, binding of Pit1-occupied enhancers to a nuclear matrin-3-rich network/architecture is a key event in effective activation of the Pit1-regulated enhancer / coding gene transcriptional program. All ChIP-seq(s) were designed to under...
ORGANISM(S): Rattus norvegicus 
2014-08-03 | E-GEOD-58009 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocampi of rats that were injected with kainic acid at postnatal day (P) 20 to induce early-life seizures and then housed in an enriched environment until P30
Neuropsychiatric consequences of poorly controlled seizures that begin in childhood can be devastating. School failure or behavioral difficulty in a child with epilepsy is common and can become the focus of concern for families. Current antiepileptic drugs compound problems with their CNS side effe...
ORGANISM(S): Rattus norvegicus 
2007-09-14 | E-GEOD-1833 | biostudies-arrayexpress
UnknownAn orthologue of Bacteroides fragilis NanH is the principal sialidase in Tannerella forsythia.
Not available
S-EPMC2681896 | biostudies-literature
GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
TranscriptomicsOccupancy and transcriptional profile of Prdm12 in posteriorized neural tissue
V1 interneurons are a class of inhibitory neurons that play an essential role in vertebrate locomotion; however, the factors contributing to their specification are poorly understood. Morphological and molecular evidence suggest that the zinc finger transcription factor Prdm12 may play a role in pro...
ORGANISM(S): Xenopus laevis 
2015-11-04 | E-GEOD-64551 | biostudies-arrayexpress
GenomicsLRP8-Reelin-regulated Neuronal (LRN) Enhancer signature underlying learning and memory formation (ChIP-Seq)
A comprehensive landscape of epigenomic events regulated by the Reelin signaling through activation of specific cohort of cis-regulatory enhancer elements (LRN-enhancers), which involves the proteolytical processing of the LRP8 receptor by the gamma-secretase activity and is required for learning an...
ORGANISM(S): Mus musculus 
2015-04-29 | E-GEOD-66701 | biostudies-arrayexpress
TranscriptomicsLRP8-Reelin-regulated Neuronal (LRN) Enhancer signature underlying learning and memory formation (RNA-Seq 1)
A comprehensive landscape of epigenomic events regulated by the Reelin signaling through activation of specific cohort of cis-regulatory enhancer elements (LRN-enhancers), which involves the proteolytical processing of the LRP8 receptor by the gamma-secretase activity and is required for learning an...
ORGANISM(S): Mus musculus 
2015-04-29 | E-GEOD-66706 | biostudies-arrayexpress
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