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TranscriptomicsSingle cell RNAseq analysis of wildtype and Igfbpl1-/- retina microglia
IGFBPL1 deficiency leads to progressive retinal neuron loss and phosphorylated Tau accumulation in the brain. To investigate the role of IGFBL1 in retina microglia homestasis and function. Total immune cells were sorted from wildtype and Igfbpl1-/- mice applied for single cell RNAseq analysis by 10X...
ORGANISM(S): Mus musculus 
2021-06-05 | GSE176204 | GEO
TranscriptomicsRNA-seq for the tissues of GGPPS knockout mice and wild type mice
Protein prenylation has multiple important physiological function, but the evidence has been to be explored. Now we found that eicosanoid metabolism homestasis was broken after GGPPS deletion in neonatal vascular smooth muscles through GGPP prenylation.
ORGANISM(S): Mus musculus 
2020-10-03 | GSE142820 | GEO
TranscriptomicsSingle cell RNAseq analysis of Igbpl1 treatment on microbead-induced glaucoma in mice
IGFBPL1 deficiency leads to progressive retinal neuron loss and phosphorylated Tau accumulation in the brain. To investigate the role of IGFBL1 in retina microglia homestasis and function. Total immune cells were sorted from microbead (MB)-induced glaucoma mice and glucoma mice treated with recombin...
ORGANISM(S): Mus musculus 
2023-07-26 | GSE226456 | GEO
TranscriptomicsAltered mRNA expression profile of GW4064 treated mouse livers compared to vehicle control
Farnesoid X receptor (FXR) is a ligand activated nuclear receptor belonging to the nuclear receptor superfamily. Bile acids (BAs) are the endogenous ligand for FXR. FXR is a master regulator of BA homestasis, including BA synthesis, metabolism, transport, and enterohepatic circulation of BAs. Beside...
ORGANISM(S): Mus musculus 
2014-07-24 | GSE57305 | GEO
UnknownThe Effects of the Combination of Oral Lactoferrin and Iron Injection on Iron Homestasis, Antioxidative Abilities and Cytokines Activities of Suckling Piglets.
Not available
S-EPMC6680753 | biostudies-literature
TranscriptomicsInvestigating RXR dependent changes in mRNA expression by using novel chemical modulators
The ligand dependent nuclear receptor subtypes RXRa, RXRb, and RXRc are key mediators in mammalian homestasis and in response to pathological conditions, e.g. inflammation and neurodegeneration. We allocated a set of RXR pan-agonists including the established agonist Bexarotene, a drug used as secon...
ORGANISM(S): Homo sapiens 
2025-05-01 | E-MTAB-15058 | biostudies-arrayexpress
UnknownThe Phytotoxin Myrigalone A Triggers a Phased Detoxification Programme and Inhibits Lepidium sativum Seed Germination via Multiple Mechanisms including Interference with Auxin Homeostasis.
Not available
S-EPMC9104956 | biostudies-literature
TranscriptomicsAltered mRNA expression profile of GW4064 treated mouse livers compared to vehicle control
Farnesoid X receptor (FXR) is a ligand activated nuclear receptor belonging to the nuclear receptor superfamily. Bile acids (BAs) are the endogenous ligand for FXR. FXR is a master regulator of BA homestasis, including BA synthesis, metabolism, transport, and enterohepatic circulation of BAs. Beside...
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-57305 | biostudies-arrayexpress
UnknownThermophilic fungus uses anthraquinones to modulate ferrous excretion, sterol-mediated endocytosis, and iron storage in response to cold stress.
Not available
S-EPMC11362841 | biostudies-literature
UnknownAccelerated development of instability-induced osteoarthritis in transgenic mice overexpressing SOST.
Not available
S-EPMC6965855 | biostudies-literature
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