Sort   by:  
 Page size 
ProteomicsPUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer
Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD081798 | Pride
Homologous recombination deficient breast cancer Pum3 
UnknownGermline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination.
Not available
S-EPMC8505423 | biostudies-literature
GenomicsStructural variant analysis of homologous recombination-deficient genomes
Homologous recombination (HR) deficiency causes DNA breaks and cytogenetic aberrations. Paradoxically, the types of DNA rearrangements specifically associated with HR-deficient cancers only minimally impact chromosomal structure. Addressing this, we combined a genome graph analysis of short-read who...
EGAS00001007186 | EGA
GenomicsEpigenomic landscape of homologous recombination deficient (HRD) triple-negative breast cancer (TNBC)
Epigenomic landscape of homologous recombination deficient (HRD) triple-negative breast cancer (TNBC)
PRJNA1075433 | ENA
Genomicsena-DATASET-EMC-29-01-2018-10:48:52:289-175 - samples
Exome sequencing data from homologous recombination deficient primary breast cancers as assessed by the functional RAD51 based HR test. There are 12 tumour samples, of which 10 also have matching normal.
EGAD00001003929 | EGA
UnknownHomologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Not available
S-EPMC7260192 | biostudies-literature
UnknownIdentifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes.
Not available
S-EPMC10504389 | biostudies-literature
UnknownMulti-scale characterisation of homologous recombination deficiency in breast cancer.
Not available
S-EPMC10621207 | biostudies-literature
GenomicsBreast cancer DNA repair
Tumors of germline BRCA1/2 mutated carriers show homologous recombination (HR) deficiency (HRD), resulting in impaired DNA double strand break (DSB) repair and high sensitivity to Poly-(ADP-Ribose)-Polymerase (PARP) inhibitors. Although this therapy is expected to be effective beyond germline BRCA1/...
EGAS00001002792 | EGA
GenomicsHomologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer
Triple negative breast cancer (TNBC) encompasses molecularly different subgroups, with a subgroup harboring evidence of defective homologous recombination (HR) DNA repair. Within a phase 2 window clinical trial, RIO trial (EudraCT 2014-003319-12), we investigate the activity of PARP inhibitors in 43...
EGAS00001004405 | EGA
Sort   by:  
 Page size