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ProteomicsPeptide probes containing a non-hydrolyzable phosphotyrosine-mimetic residue as a tool for tyrosine phosphatomics
Protein tyrosine phosphatases (PTPs) cooperate with protein tyrosine kinases to regulate intracellular tyrosine phosphorylation levels, and their dysfunction is associated with various diseases. However, due to the low abundance of PTPs in cells, comprehensive analysis requires an enrichment step pr...
ORGANISM(S): Homo Sapiens (human) 
2021-10-27 | PXD025038 | JPOST Repository
TranscriptomicsBT474 tumors in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34523 | biostudies-arrayexpress
TranscriptomicsPrimary TNBC tumor in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2012-01-16 | E-GEOD-35118 | biostudies-arrayexpress
UnknownDopamine regulates phosphorylation of VEGF receptor 2 by engaging Src-homology-2-domain-containing protein tyrosine phosphatase 2.
Not available
S-EPMC2736867 | biostudies-literature
UnknownExploring the Allosteric Mechanism of Src Homology-2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP2) by Molecular Dynamics Simulations.
Not available
S-EPMC7719740 | biostudies-literature
UnknownSalicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Not available
S-EPMC2842125 | biostudies-literature
UnknownT Cell-Specific Deficiency of Src Homology 2-Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation.
Not available
S-EPMC12314549 | biostudies-literature
UnknownSrc Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin.
Not available
S-EPMC8063055 | biostudies-literature
UnknownSrc homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
Not available
S-EPMC5602405 | biostudies-literature
UnknownRetinal Src homology region 2-containing protein tyrosine phosphatase 2 silencing alleviates diabetic retinopathy via suppressing inflammatory response and oxidative stress by regulating Yes-associated protein 1 activity.
Not available
S-EPMC9388342 | biostudies-literature
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