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GenomicsCBX3 Regulates Efficient RNA Processing Genome Wide
HP1 alpha, beta, and gamma play an evolutionarily conserved role in the formation and maintenance of heterochromatin. In addition, some HP1 family members may also participate in transcriptional regulation of genes. Recently, HP1 gamma binding to the bodies of a subset of genes has been observed in ...
ORGANISM(S): Homo sapiens 
2012-05-24 | E-GEOD-28115 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of breast cancer (HCC1954) and normal breast cells (HMEC)
While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors as well as changes in chromatin modifications as caused by genetic mutations of the chromatin-modifying machinery. Howeve...
ORGANISM(S): Homo sapiens 
2011-09-16 | E-GEOD-29119 | biostudies-arrayexpress
GenomicsBisulfite sequencing of ChIP DNA on breast cancer cells (HCC1954)
While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors as well as changes in chromatin modifications as caused by genetic mutations of the chromatin-modifying machinery. Howeve...
ORGANISM(S): Homo sapiens 
2011-09-16 | E-GEOD-29120 | biostudies-arrayexpress
TranscriptomicsDifferential roles of promoters, enhancers, and insulators in cell-type specific gene expression
Chromatin immunoprecipitation was performed using antibodies against CTCF and formaldehyde crosslinked chromatin from K562 Chromatin cells. The immunoprecipitated DNA was amplified, fluorescently labeled and hybridized to a 391K element tiling array based on NCBI35 build of the human genome (hg17) t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-8098 | biostudies-arrayexpress
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