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TranscriptomicsRUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
RUNX1 is a transcription factor functioning both as an oncogene and a tumor suppressor in breast cancer. RUNX1 alters chromatin structure in cooperation with chromatin modifier and remodeling enzymes. In this study, we examined the relationship between RUNX1-mediated transcription and genome organiz...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-75070 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression between MCF10A and MCF7 cells
These RNA-seq data were generated to correlate with genomic interaction data in a related Hi-C analysis. MCF10A is a normal-like mammary epithelial cell line and MCF7 is a transformed estrogen responsive breast cancer cell line derived from a metastatic site; both are commonly used in models of bre...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-71862 | biostudies-arrayexpress
TranscriptomicsChromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells
Background: Higher-order chromatin structure is often perturbed in cancer and other pathological states. Although several genetic and epigenetic differences have been charted between normal and breast cancer tissues, changes in higher-order chromatin organization during tumorigenesis have not been f...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-66733 | biostudies-arrayexpress
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