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TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
TranscriptomicsThe histone chaperone Spt6 is required for AID target determination through H3K4me3 regulation
H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during class-switch recombination (CSR). The histone chaperone complex facilitates chromatin transcription (FACT) is responsible f...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-35334 | biostudies-arrayexpress
TranscriptomicsAcetylated Histone Reader Brd4 functions as Repair Adaptor in Immunoglobulin Class Switch Recombination
Class Switch Recombination (CSR) is a B cell specific genomic alteration induced by activation induced cytidine deaminase (AID)-dependent DNA break, followed by repair and recombination at the immunoglobulin heavy-chain locus. The involvement of several chromatin-associated factors in promoting AID-...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-52239 | biostudies-arrayexpress
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