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UnknownImmune checkpoint inhibitors win the 2018 Nobel Prize.
Not available
S-EPMC6889239 | biostudies-literature
TranscriptomicsComparison of gene expression in Wild type and T cell-specific conditional Trim28 KO in TCR stimulated and un-stimulated naive CD4 positive and T regulatory cells
A microarray study was performed in unstimulated and TCR-stimulated CD4 + T cells and Treg in wild type and conditional Trim28 KO mice to identify genes that are regulated by Trim28. These experiments constitute a portion of the study described below: Paper Abstract: Peripheral T cell activatio...
ORGANISM(S): Mus musculus 
2012-04-28 | E-GEOD-32224 | biostudies-arrayexpress
TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
TranscriptomicsThe Cellular and Molecular Origin of Tumor-associated Macrophages
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and immune defense against pathogens, macrophages are being rediscovered as regulators of several diseases including cancer. Here we show that in mice, mammary tumor growth induces the accumulation of tumor-associ...
ORGANISM(S): Mus musculus 
2014-04-18 | E-GEOD-56755 | biostudies-arrayexpress
GenomicsMus musculus
The Cellular and Molecular Origin of Tumor-associated Macrophages
PRJNA244814 | ENA
TranscriptomicsAcetylated Histone Reader Brd4 functions as Repair Adaptor in Immunoglobulin Class Switch Recombination
Class Switch Recombination (CSR) is a B cell specific genomic alteration induced by activation induced cytidine deaminase (AID)-dependent DNA break, followed by repair and recombination at the immunoglobulin heavy-chain locus. The involvement of several chromatin-associated factors in promoting AID-...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-52239 | biostudies-arrayexpress
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