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TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
TranscriptomicsProtein affects gene expression and prevents lipid accumulation in the liver in mice
Obesity and associated increased prevalence of non-alcoholic fatty liver (NAFLD) disease is suggested to be positively modulated by a high protein (HP) diet in humans and rodents. The aim was to detect mechanisms by which a HP diet prevents hepatic lipid accumulation by means of transcriptomics. To ...
ORGANISM(S): Mus musculus 
2012-11-21 | E-GEOD-37897 | biostudies-arrayexpress
TranscriptomicsResistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in proximal colon of male pigs
Consumption of resistant starch (RS) has been associated with various intestinal health benefits, but knowledge on its effects on global gene expression in the colon is limited. The main objective of the current study was to identify genes affected by RS in the proximal colon to infer which biologic...
ORGANISM(S): Sus scrofa 
2013-10-18 | E-GEOD-45554 | biostudies-arrayexpress
UnknownGut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon.
Not available
S-EPMC4538683 | biostudies-literature
TranscriptomicsMaternal exposure to a Western-style diet causes differences in microbiota composition and gene expression in the intestine of suckling mouse pups
During the last few decades, the long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident, but the effects of maternal nutrition on the developing intestine are currently still relatively underexplored. In this study, we investigated in mic...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-72705 | biostudies-arrayexpress
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