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GenomicsTranscription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites [S-phase/M-phase synchronized cells]
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis, and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human col...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51290 | biostudies-arrayexpress
GenomicsH2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics [ChIP-seq]
While it has been clearly established that well positioned H2A.Z-containing nucleosomes flank the nucleosome depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here th...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41371 | biostudies-arrayexpress
TranscriptomicsComparative analysis of transcriptome profiles of G. hirsutum L. cv. MCU5 and its fuzzless-lintless mutant during fiber development stages.
Cotton is one of the most commercially important Fiber crops in the world and used as a source for natural textile Fiber and cottonseed oil. The fuzzless-lintless ovules of cotton mutants are ideal source for identifying genes involved in Fiber development by comparing with Fiber bearing ovules of w...
ORGANISM(S): Gossypium hirsutum 
2013-06-14 | E-GEOD-38490 | biostudies-arrayexpress
TranscriptomicsListeria monocytogenes strain F2365 has reduced ability to survive stress while maintaining virulence characteristics
Listeria monocytogenes strain F2365 was the first strain representative of serotype 4b (lineage I) to be sequenced in 2004, suggesting it could become the model organism for this serotype, which is associated with most human outbreaks of listeriosis worldwide to date. F2365 itself is an outbreak st...
ORGANISM(S): Listeria monocytogenes 
2013-06-01 | E-GEOD-42730 | biostudies-arrayexpress
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
TranscriptomicsResponse of tobacco cells to Glucan elicitor
We have previously reported that the responses of tobacco tissues treated with AaGlucan are similar to those for laminarin [1]. To better understand the overall responses and signaling pathways in tobacco, we have identified here AaGlucan and laminarin early response genes, using a custom 16K BY-2 m...
ORGANISM(S): Nicotiana tabacum 
2007-10-16 | E-GEOD-6948 | biostudies-arrayexpress
TranscriptomicsEMT-induced stemness and tumorigenicity are fueled by an oncogenic EGF/Ras pathway
Pre-EMT GIF14 cells treated with TGF-M-NM-21 Total RNA obtained from isolated GIF-14 cells from untreated and TGF-M-NM-21-treated sample
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-44055 | biostudies-arrayexpress
TranscriptomicsEarly response of gene expression in the distal intestine of Atlantic salmon (Salmo salar L.) during the development of soybean meal induced enteritis
In the present study a 44k oligonucleotide salmonid microarray, qPCR and histology were used to investigate transcriptomic responses in the distal intestine during the first week of oral exposure to soybean meal in order to gain insight into early molecular response mechanisms. Intestinal tissue sam...
ORGANISM(S): Salmo salar 
2012-12-17 | E-GEOD-37457 | biostudies-arrayexpress
TranscriptomicsCorrelation of transcriptomic responses and metal bioaccumulation in Mytilus edulis L. reveals early indicators of stress
Marine biomonitoring programs in the U.S. and Europe have historically relied on monitoring tissue concentrations of bivalves to monitor contaminant levels and ecosystem health. By integrating M-bM-^@M-^Xomic methods with these tissue residue approaches we can uncover mechanistic insight to help li...
ORGANISM(S): Mytilus edulis 
2014-06-20 | E-GEOD-58649 | biostudies-arrayexpress
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