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TranscriptomicsHigh-frequency stimulation of the ventrolateral thalamus regulates gene expression in hippocampus, motor cortex and caudate-putamen
Transcriptional profiling of rat hippocampus comparing rats subjected to chronic (1 hour daily during 14 days) vetrolateral thalamus stimulation (DBS group) with sham operated rats (with electrode placement but without stimulation) and with naive rats. Three-condition experiment, DBS, sham and nai...
ORGANISM(S): Rattus norvegicus 
2011-06-30 | E-GEOD-25860 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dicer knock-out nociceptive sensory neurons from mice to investigate the roles of microRNAs in nociception
We used the Nav1.8-Cre to delete Dicer in mouse nociceptive sensory neurons to investigate the roles of microRNAs in nociception.
ORGANISM(S): Mus musculus 
2010-01-01 | E-MEXP-1461 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling of Hippocampal CA1 After Early Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies for Epilepsy
Injury of the CA1 subregion induced by a single injection of kainic acid (1M-CM-^WKA) is attenuated when juvenile animals (P20) have a history of two sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early life conditioning...
ORGANISM(S): Rattus norvegicus 
2013-02-14 | E-GEOD-44031 | biostudies-arrayexpress
TranscriptomicsTranscription factor Runx1 cooperates with MyoD and c-Jun to regulate the balance of myoblast proliferation/differentiation [Expression Study]
Runx1 is expressed in regenrating muscle, specifically in the muscle adult stem cells- the satellite cells. Its exact role and target genes were yet to be identified This experiment aimed at determining the Runx1 regulated genes in muscle regeneration, specifically in Satellite cells To elucidate th...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-55556 | biostudies-arrayexpress
TranscriptomicsscRNAseq datasets of human brain organoids generated for the manuscript "Morphodynamics of human early brain organoids
Here we have provided scRNAseq datasets of unguided human brain organoids. The organoids were sequenced as a 1) Timecourse, 2) With different extracellular matrix treatments, 3) chemical treatment and 4) from organoids ere generated with a gene knockout cell line. Brain organoids enable the mechanis...
ORGANISM(S): Homo sapiens 
2025-04-30 | E-MTAB-15057 | biostudies-arrayexpress
TranscriptomicsFate and State Transitions during Human Blood Vessel Organoid Development: Perturbation
Human blood vessel organoids (hBVOs) have emerged as a system to model human vascular development and disease. Here, we use genetic and signaling pathway perturbations to reconstruct hBVO development. We use single-cell genetic perturbations to identify transcription factors (TFs) and receptors invo...
ORGANISM(S): Homo sapiens 
2025-03-01 | E-MTAB-14839 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Comparisons of Control and Schizophrenia-Patient derived hiPSC-derived NPCs
Cell-based models of many neurological and psychiatric diseases, established by reprogramming patient somatic cells into human induced pluripotent stem cells (hiPSCs), have now been reported. While numerous reports have demonstrated that neuronal cells differentiated from hiPSCs are electrophysiolo...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-63738 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in Daphnia magna Suggests Distinct Modes of Action and Bioavailability for ZnO nanoparticles and Zn ions
Zinc Oxide nanoparticles (ZnO NPs) are being rapidly developed for use in consumer products, wastewater treatment and chemotherapy providing several possible routes for ZnO NP exposure to humans and aquatic organisms. Recent studies have shown that ZnO NPs undergo rapid dissolution to Zn+2, but the...
ORGANISM(S): Daphnia magna 
2010-12-31 | E-GEOD-22051 | biostudies-arrayexpress
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