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GenomicsUsing TraDIS-Xpress to find the genes that affect susceptibility to common food preservatives
The mechanisms of action of common food preservatives are poorly understood. As there is a drive to develop alternative preservatives, understanding the mechanisms of action of current preservatives can inform development of novel food preservatives to ensure their efficacy. Here we used TraDIS-Xpre...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2025-03-14 | E-MTAB-14856 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Leptospirillum ferriphilum DSM 14647 cells treated with quorum sensing signal compounds
Differential gene expression analysis of Leptospirillum ferriphilum DSM 14647 cells treated with quorum sensing singnal compounds. Briefly, Leptospirillum ferriphilum DSM 14647 cells were grown to early stationary phase in Mackintosh basal salt solution (Mac medium) pH 1.8 (Mackintosh 1978) with 71....
ORGANISM(S): Leptospirillum ferriphilum DSM 14647 
2021-03-01 | E-MTAB-9845 | biostudies-arrayexpress
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
UnknownTwo-Year Outcomes With a Next-Generation Left Atrial Appendage Device: Final Results of the PINNACLE FLX Trial.
Not available
S-EPMC10111496 | biostudies-literature
UnknownIdentification of cells of leukemic stem cell origin with non-canonical regenerative properties.
Not available
S-EPMC11031376 | biostudies-literature
GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
UnknownWithin-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study.
Not available
S-EPMC7783933 | biostudies-literature
TranscriptomicsMicroarray transcriptional analysis of leptin signaling knockdown and rescue in 72-hour post fertilization zebrafish
The effects of leptin-A morpholino oligonucleotides and recombinant leptin-A on embryonic zebrafish transcriptome content were evaluated using Affymetrix 1.1 ST gene array strips.
ORGANISM(S): Danio rerio 
2018-04-02 | E-MTAB-6548 | biostudies-arrayexpress
TranscriptomicsNovel linkages between DCE-MRI and genomic profiling in locally advanced and inflammatory breast cancer
Gene expression signatures have the capacity to identify clinically significant features of breast cancer and can predict which individual patients are likely to be resistant to neoadjuvant therapy, thus providing the opportunity to guide treatment decisions. Data used in publication: Clin Cancer Re...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52322 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of normal and cancerous human breast samples
To assess changes in DNA methylation state associated with breast cancer we analyzed DNA from normal and cancerous breast specimens on CpG islands microarray using methylation-sensitive enzyme McrBC for target preparation. Cy3 was used for McrBC cut sample, Cy5 was used for reference Mock sample.
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-881 | biostudies-arrayexpress
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