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UnknownMolecular prognostic prediction in liver cirrhosis.
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S-EPMC4579874 | biostudies-literature
TranscriptomicsA preclinical mouse model of nonalcoholic steatohepatitis and hepatocellular cancer that mimics human disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67680 | biostudies-arrayexpress
TranscriptomicsCombining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is among the top-five cancer killers worldwide. Here, we describe our analysis of 20 gene signatures with reported prognostic value in a cohort of patients with early stage HCC treated with surgical resection. Methods: We performed gene-expression profiling...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20140 | biostudies-arrayexpress
TranscriptomicsHeterogeneity of gene-expression profiles of hepatocellular carcinoma tumors
BACKGROUND & AIMS: In approximately 70% of patients with hepatocellular carcinoma (HCC) treated by resection or ablation, disease recurs within 5 years. Although gene expression signatures have been associated with outcome, there is no method to predict recurrence based on combined clinical, patholo...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-56140 | biostudies-arrayexpress
TranscriptomicsMicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor due to activation of multiple cellular pathways and molecular alterations. Herein, we report the first molecular classification of 89 HCC based on the expression of 358 microRNAs and integrative genomic analysis. Three main subclass...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20596 | biostudies-arrayexpress
TranscriptomicsA genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54102 | biostudies-arrayexpress
TranscriptomicsIntegrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes
BACKGROUND & AIMS: Cholangiocarcinoma, the second most common liver cancer, can be classified as intrahepatic (ICC) or extrahepatic. We performed an integrative genomic analysis of ICC samples from a large series of patients. METHODS: We performed gene expression profile, high-density single nucleot...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-33327 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of uhrf1 mutant zebrafish
UHRF1 (Ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication, is essential for maintaining DNA methylation patterns during cell division and is suggested to direct additional repressive epigenetic marks. Uhrf1 mutation in zebrafish results...
ORGANISM(S): Danio rerio 
2015-02-09 | E-GEOD-55339 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma
Gene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma tissues obtained at the time of surgical resection. Gene-expression profiling was performed using formalin-fixed, paraffin-embedded hepatocellular carcinoma tissues obtained at the time of surgical resection...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-19977 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers and liver tumors from mice fed high-fat diet and high fructose-glucose solution for 52 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67679 | biostudies-arrayexpress
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