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MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
MetabolomicsGut microbiota-derived metabolite pantetheine modulates host lipid metabolism to protect against obesity

Obesity is intricately linked to the gut microbiota, yet the microbial effectors and molecular mechanisms that mediate this association remain poorly defined. Fecal microbiome analysis revealed a consistent depletion of the commensal bacterium Roseburia inulinivorans in obese individuals, with it...

2025-10-15 | MTBLS13142 | MetaboLights
MetabolomicsFatty acid synthesis in colorectal cancer: characterization of lipid metabolism in serum, tumour, and normal host tissues
The objective of the experiment was to compare serum fatty acid metabolite abundance between individuals with varying clinical stages of colorectal cancer (stage I-IV) and age-and-gender matched disease-free controls. Fatty acid metabolite abundance was compared between locoregional (stage I-III) an...
2016-12-15 | MTBLS27 | MetaboLights
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
MetabolomicsMultiomics of yaks reveals significant contribution of microbiome into host metabolism

BACKGROUND: Grazing yearly on pasture is a traditional practice for yaks, which cannot meet the requirements of yak production since the insufficient forage supplied in the cold season results in a long production cycle. An intensive feeding system increasing production efficiency has been select...

2024-10-01 | MTBLS10450 | MetaboLights
MetabolomicsInteraction between rhizobacterial community and host root metabolism influences poplar salt tolerance

Poplar seedlings were cultivated in saline soil with low salt concentrations for 120 days, after which root tissues were harvested for untargeted metabolomic analysis. For each genotype, roots of three to four seedlings were pooled to form one biological replicate, with four biological replicates...

2026-05-15 | MTBLS14479 | MetaboLights
MetabolomicsT cell metabolism during graft-versus-host disease(CAB 311)
Not available
ORGANISM(S): Mus musculus 
ST000181 | MetabolomicsWorkbench
MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
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