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TranscriptomicsDistinct Ldb1/NLI complexes orchestrate γ-globin repression and re-activation through ETO2 in human adult erythroid cells.
The Ldb1/GATA-1/TAL1/LMO2 complex mediates long range interaction between the β-globin locus control region (LCR) and gene in adult mouse erythroid cells but whether this complex mediates chromatin interactions at other developmental stages or in human cells is unknown. We investigated human NLI (Ld...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-30047 | biostudies-arrayexpress
TranscriptomicsGene Density, Transcription and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains (Hi-C analysis of Drosophila melanogaster Kc167 genome)
The mechanisms responsible for the establishment of physical domains in metazoan chromosomes are poorly understood. Here we find that physical domains in Drosophila chromosomes are demarcated at regions of active transcription and high gene density that are enriched for transcription factors and spe...
ORGANISM(S): Drosophila melanogaster 
2012-10-04 | E-GEOD-38468 | biostudies-arrayexpress
UnknownMAP3K1-targeting therapeutic artificial miRNA suppresses the growth and invasion of breast cancer in vivo and in vitro.
Not available
S-EPMC4700027 | biostudies-literature
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