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TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-09-15 | E-GEOD-61400 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [04_Cerebellun_and_brain]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Mus musculus 
2014-09-15 | E-GEOD-61324 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [01_fibroblasts_patientAndcarrier]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-61320 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [03_AOA2_patient_blood_2011]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-61322 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [02_fibroblasts_transfected]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-61321 | biostudies-arrayexpress
TranscriptomicsThe effect of GW3965 and dexamethasone on gene expression of rat livers
GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase) a key enzyme of gluconeogenesis, and suppress the immune system which makes them one of the most important therapeutic agents in th...
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-29912 | biostudies-arrayexpress
TranscriptomicsG-CSF receptor targeting in inflammatory arthritis
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-76966 | biostudies-arrayexpress
TranscriptomicsGENCODE PCR-Seq Batch M2
As part of the ENCODE consortium the GENCODE project is producing a reference gene set through manual and automated gene prediction. Selected transcript models are verified experimentally by RT-PCR amplification of at least one of their unique splice junctions followed by high-throughput sequencing....
ORGANISM(S): Mus musculus 
2016-04-28 | E-MTAB-4644 | biostudies-arrayexpress
TranscriptomicsGENCODE PCR-Seq Batch M1
As part of the ENCODE consortium the GENCODE project is producing a reference gene set through manual and automated gene prediction. Selected transcript models are verified experimentally by RT-PCR amplification of at least one of their unique splice junctions followed by high-throughput sequencing....
ORGANISM(S): Mus musculus 
2015-01-22 | E-MTAB-3261 | biostudies-arrayexpress
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