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UnknownEcho2Pheno: a deep-learning application to uncover echocardiographic phenotypes in conscious mice.
Echocardiography, a rapid and cost-effective imaging technique, assesses cardiac function and structure. Despite its popularity in cardiovascular medicine and clinical research, image-derived phenotypic measurements are manually performed, requiring expert knowledge and training. Notwithstanding gre...
S-EPMC10290584 | biostudies-literature
TranscriptomicsTranscriptomics study on the effect of alternative oxidase expression in Bcs1l mutant (S78G) mice (Mus musculus)
The dataset contains 72 RNA-seq samples obtained from adult (P150) C57BL/6JCrl mice. Samples are from total heart, liver and kidney tissue. Four different genotypes are included in the data: 1) wild type, 2) transgenic Ciona intestinalis AOX in Rosa26 locus (Szibor et al. 2017, DOI: 10.1242/dmm.0278...
ORGANISM(S): Mus musculus 
2018-11-16 | E-MTAB-7416 | biostudies-arrayexpress
ProteomicsFemale mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. We have demonstrated that paladin has a predominant vascular expression pattern and shifts from endothelial to mural cells during mouse development. We have now characterized the...
ORGANISM(S): Mus Musculus (mouse) 
2017-11-01 | PXD005625 | JPOST Repository
UnknownRNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure.
Epitranscriptomic events such as adenosine-to-inosine (A-to-I) RNA editing by ADAR can recode mRNAs to translate novel proteins. Editing of the mRNA that encodes actin crosslinking protein Filamin A (FLNA) mediates a Q-to-R transition in the interactive C-terminal region. While FLNA editing is conse...
S-EPMC6166124 | biostudies-literature
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
TranscriptomicsMAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-like Behavior in Adults
MAP kinase signaling has been implicated in brain development, long-term memory, and the response to antidepressants. Inducible Braf knockout mice enabled us to unravel a new role of neuronal MAPK signaling for emotional behavior. Braf mice that were induced during adulthood showed normal anxiety bu...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-33618 | biostudies-arrayexpress
UnknownIdentification of genetic elements in metabolism by high-throughput mouse phenotyping.
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. Here, we generate and analyze metabolic phenotypic data ...
S-EPMC5773596 | biostudies-literature
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