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Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
abundance based on Spectral counting, Pancreatic_metastatic, Interaction consistency score: 21.5, Coverage: 32
ORGANISM(S): 9606 
2014-00-00 | 4148541313 | PAXDB
Clinical Implications of Genomic Alterations in the Tumour and Circulation of Pancreatic Cancer Patients
Pancreatic adenocarcinoma has the worst mortality of any solid cancer. To evaluate the clinical implications of genomic alterations in this tumor type, we performed whole-exome analyses of 24 tumors, targeted genomic analyses of 77 tumors, and used non-invasive approaches to examine tumor-specific ...
Data Access Committee EGAC00001000358
These are only the whole exome sequences
Sequencing of untreated pancreatic cancer metastases and primary tumor sections.
This is the complete dataset (exome and genome) for the EGAS00001000974 study.
Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed whole genome sequencing on four MPNST...
The extent of heterogeneity of driver gene mutations present in naturally occurring metastases is largely unknown, i.e. treatment-naïve metastatic disease. To address this issue, 60x whole genome sequencing of 26 metastases from 4 patients was carried out. We found that the identical driver gene m...
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