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MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
MetabolomicsMetabolomics-based elucidation of active metabolic pathways in erythrocytes and HSC-derived reticulocytes
Not available
ORGANISM(S): Homo sapiens 
ST000403 | MetabolomicsWorkbench
TranscriptomicsHSC-3 cells (control) vs. HSC-3-5 cells [tongue]
HSC-3-5 cells, which drived from human HSC-3 cells via transwell invasion assay was high invasive.Tumor cells were injected into the tongue of SCID mice. After 1 week, transcriptional profiling of human HSC-3 tumor comparing with high invasive HSC-3-5 tumor. Goal was to determine the effects of inv...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-39725 | biostudies-arrayexpress
TranscriptomicsHSC-3 cells (control) vs. HSC-3-5 cells [subcutaneous tumor]
HSC-3-5 cells, which drived from human HSC-3 cells via transwell invasion assay was high invasive.Tumor cells were injected into the flank of SCID mice. After 6 weeks, transcriptional profiling of human HSC-3 tumor comparing with high invasive HSC-3-5 tumor. Goal was to determine the effects of inv...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-39726 | biostudies-arrayexpress
TranscriptomicsHSC-3 cells (control) vs. HSC-3-5 cells [cell line]
HSC-3-5 cells were derived from human HSC-3 cells via transwell invasion assay. Transcriptional profiling of human HSC-3 cells comparing with high invasive HSC-3-5 cells. Goal was to determine the effects of invasion on global HSC-3-5 gene expression during tumor metastasis. Two-condition experimen...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-39723 | biostudies-arrayexpress
GenomicsGenome-wide maps of DNA cytosine methylation state in during normal differentiation commitment in hematopoietic stem cells (HSC) and in Special AT-rich sequence-binding protein1 (Satb1) - deficient HSC
Our data show Satb1 deficiency leads to alterations in DNA cytosine methylation and a commitment-primed epigenetic state in HSCs. Examination of DNA cytosine methylation in wild type HSC and differentiation-committed progenitors as well as in wild type HSC and HSC lacking Satb1 (n=2 each).
ORGANISM(S): Mus musculus 
2013-04-07 | E-GEOD-44304 | biostudies-arrayexpress
TranscriptomicsAttenuation of miR-126 activity expands HSC in vivo without exhaustion
Life-long blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. MicroRNAs (miRNAs) coordinately regulate multiple targets within signaling networks making them attractive candid...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-40458 | biostudies-arrayexpress
Transcriptomics3’-Seq HSC/MPP1-4
Here, we present a 3’-Seq dataset of ex vivo isolated mouse multipotent hematopoietic stem cells (HSC) and multipotent progenitor cells (MPP1-4)
ORGANISM(S): Mus musculus 
2020-06-01 | E-MTAB-7391 | biostudies-arrayexpress
TranscriptomicsMRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development
Chemokine signaling is important for the seeding of different sites by hematopoietic stem cells during development. Serum Response Factor (SRF) controls multiple genes governing adhesion and migration, mainly by recruiting members of the Myocardin-Related Transcription Factor (MRTF) family of G-acti...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-63820 | biostudies-arrayexpress
TranscriptomicsHSC-3 cells (control) vs. HSC-3-5 cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-39729 | biostudies-arrayexpress
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