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TranscriptomicsGene expression profiling of LT-HSCs and ST-HSCs conditionally expressing MLL-ENL
We have developed a new conditional transgenic mouse showing that MLL-ENL, at an endogenous-like expression level, induces leukemic transformation selectively in LT-HSCs. To investigate the molecular mechanism of leukemic transformation in LT-HSCs conditionally expressing MLL-ENL, we preliminarily p...
ORGANISM(S): Mus musculus 
2013-07-17 | E-GEOD-48539 | biostudies-arrayexpress
GenomicsTranscriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.
Transcriptome analysis of bulk-HSCs, LT-HSCs and ST-HSCs.
PRJNA941818 | ENA
TranscriptomicsExpression profiling of Irgm1-/- (Lrg-47) HSCs
To assess gene expression changes in Irgm1 (Lrg-47) deficient HSCs Keywords: genetic modification, knockout A total of 6 samples were analyzed: 3 experimental replicates of Irgm1 HSCs were compared with 3 control replicates of WT HSCs
ORGANISM(S): Mus musculus 
2011-06-22 | E-GEOD-11591 | biostudies-arrayexpress
TranscriptomicsIFNa activates dormant HSCs in vivo
Maintenance of the blood system is dependent on dormant haematopoietic stem cells (HSCs) with long-term self-renewal capacity. Upon injury these cells are induced to proliferate in order to quickly re-establish homeostasis. The signalling molecules promoting the exit of HSCs out of the dormant stage...
ORGANISM(S): Mus musculus 
2009-01-15 | E-GEOD-14361 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in WT and Alox15-/- HSCs
To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, Alox5-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sc...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29348 | biostudies-arrayexpress
ProteomicsRad21-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation
MTD project_description Inflammation and decreased stem cell function characterize organism aging, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells exhibit increased ground-stage NF-κB activity, which enhan...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-28 | PXD011537 | Pride
Hematopoietic stems cells Inflammation Aging 
TranscriptomicsRole of de novo DNA methyltransferases in hematopoietic stem cells (RNA-seq)
To investigate the global transcriptome expression in Dnmt3ab dKO HSCs, we performed high-throughput sequencing of Poly A+ RNA (RNA-Seq) from purified HSCs (SP-KSL-CD150+). With biological duplicates, more than 200 million reads in total for each genotype of HSC were obtained. Mouse hematopoietic st...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50775 | biostudies-arrayexpress
GenomicsAging Decline of LEPR+ HSCs
Aging Decline of LEPR+ HSCs
PRJNA913011 | ENA
GenomicsGene expression profile of HSCs and ANGPTL2 treated HSCs Transcriptomes
Gene expression profile of HSCs and ANGPTL2 treated HSCs Transcriptomes
PRJNA715219 | ENA
TranscriptomicsRNA-seq of mouse wildtype HSCs purified from recipient mice co-transplanted with wildtype or different types of lymphoid cell deficient HSCs
To investigate how HSCs functionally compensate for the B cell deficiencies of other HSCs within an organism, we co-transplanted wildtype (WT) HSCs and lineage-deficient HSCs into lethally irradiated WT recipient mice. WT HSCs were then purified from the bone marrow of recipient mice for RNA isolati...
ORGANISM(S): Mus musculus 
2018-06-14 | E-MTAB-6776 | biostudies-arrayexpress
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