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ProteomicsTMT-based quantitative proteomics to study CHN-1/HSP-1 complex substrate turnover in C. elegans
The wild type (WT) and HSP-1 EEYD (worms generating endogenously mutated HSP-1) C. elegans were cultured under normal conditions (20 degrees) or exposed to 30 degrees for 16 hours as L4 larvae (referred to as heat stress/HS). In WT worms undergoing HS, the activity of CHN-1 ubiquitin ligase is antic...
ORGANISM(S): Caenorhabditis elegans 
2024-11-08 | PXD048200 | Pride
E3 ligase/chaperone C. elegans Chn-1 (human ortholog chip) Hsp-1 (human ortholog hsp-70) 
UnknownThe C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity.
Not available
S-EPMC4590010 | biostudies-literature
UnknownMutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
Not available
S-EPMC4863665 | biostudies-literature
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