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GenomicsCell-specific ablation of Hsp47 defines the collagen producing cells in the injured heart
Cell-specific ablation of Hsp47 defines the collagen producing cells in the injured heart
PRJNA531932 | ENA
TranscriptomicsTranscription profiling of human LX-2 hepatic stellate cells following treatment with TGF-beta
MicroRNA-29 regulates HSP47 expression and collagen production in activated hepatic stellate cells
ORGANISM(S): Homo sapiens 
2010-09-12 | E-TABM-761 | biostudies-arrayexpress
TranscriptomicsCell-specific ablation of Hsp47 defines the collagen producing cells in the injured heart
Overall goal: To elucidate fibroblast-specific role of Hsp47 in fibroblast activation, collagen production, and cardiac fibrosis and their differentiation to myofibroblasts. Purpose of analysis: To generate transcriptional profile of HSP47-deficient fibroblasts in the context of pathological cardiac...
ORGANISM(S): Mus musculus 
2019-08-22 | GSE129612 | GEO
TranscriptomicsTargeting the HSP47-Collagen Axis Inhibits Brain Metastasis by Reversing M2 Microglial Polarization and Restoring Anti-Tumor Immunity
Brain metastases (BrMs) are the leading cause of death in patients with solid cancers. BrMs exhibit a highly immunosuppressive milieu and poor response to immunotherapies; however, the underlying mechanism remains largely unclear. Here, we show that upregulation of HSP47 in tumor cells drives metast...
ORGANISM(S): Mus musculus 
2024-03-22 | GSE261941 | GEO
UnknownIdentification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors.
Not available
S-EPMC8301893 | biostudies-literature
GenomicsTargeting the HSP47-Collagen Axis Inhibits Brain Metastasis by Reversing M2 Microglial Polarization and Restoring Anti-Tumor Immunity
Targeting the HSP47-Collagen Axis Inhibits Brain Metastasis by Reversing M2 Microglial Polarization and Restoring Anti-Tumor Immunity
PRJNA1089612 | ENA
UnknownHSP47 levels determine the degree of body adiposity.
Not available
S-EPMC10640548 | biostudies-literature
UnknownPhotoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly.
Not available
S-EPMC6498102 | biostudies-literature
UnknownCollagen's primary structure determines collagen:HSP47 complex stoichiometry.
Not available
S-EPMC8626583 | biostudies-literature
ProteomicsAdministration of recombinant HSP47 as a new therapeutic approach to stimulate collagen secretion and ameliorate ECM in osteogenesis imperfecta
Collagen misfolding, reduced collagen secretion and incorporation into the extracellular matrix, and impaired collagen organization are common features both in a physiological condition like aging and in pathological conditions like genetic diseases caused by defects in collagen or collagen related ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047320 | Pride
Proteomics  nanolc-ms/ms 
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