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ProteomicsGlobal proteome changes of normal NIH 3T3 versus Ras-transformed NIH cells treated with 3 different Hsp90 inhibitors (geldanamycin, PU-H71 and pochoxime A)
Heat shock protein 90 (Hsp90) is a major hub in the protein network that maintains cellular homeostasis and function. The qualitative and quantitative changes and rewiring of this protein network in tumor cells make them vastly dependent on Hsp90, and as a consequence its inhibition creates a profou...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-11 | PXD009055 | JPOST Repository
TranscriptomicsTranscription profiling of Arabidopsis plants after heat shock or treatment with HSP90 inhibitors (geldanamycin and radicicol)
Effect of heat shock or HSP90 inhibitors (geldanamycin and radicicol) on wild type Arabidopsis thaliana.
ORGANISM(S): Arabidopsis thaliana 
2007-06-01 | E-ATMX-12 | biostudies-arrayexpress
GenomicsHeat-shock protein 90 globally targets paused promoters and regulates environment-induced gene expression
In this study we provide evidence that Hsp90 binds chromatin at specific sites close to several TSS in Drosophila S2 cell line. In addition of finding a preference for stalled promoter regions of annotated genes, we uncover many intergenic Hsp90 binding sites coinciding with non-annotated transcript...
ORGANISM(S): Drosophila melanogaster 
2012-05-14 | E-GEOD-31226 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis thaliana with reduced HSP90 levels
The molecular chaperone HSP90 aids the maturation of a diverse but select set of metastable protein clients, many of which are key to a variety of signal transduction pathways. HSP90 function has been best investigated in animal and fungal systems, where inhibition of the chaperone has exceptionall...
ORGANISM(S): Arabidopsis thaliana 
2008-06-15 | E-GEOD-7796 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult T cell leukemia cell lines to investigate the biological pathways of Hsp90 inhibitors
Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma (Mitsiades e...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-12287 | biostudies-arrayexpress
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
TranscriptomicsIdentification of targets regulated by MLL1 in response to HSP90 inhibitors
MLL1 WT or KO MEF with and without HSP90 inhibitor treatment MEF cells were seeded in 6-well plates for 3d with 100ng/ml doxycycline prior to treatment with 0.1% DMSO or 100nM AUY922 for 3h
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-56492 | biostudies-arrayexpress
TranscriptomicsRadicicol treatment of Drosophila cells
Drosophila S2 cells were treated with Heat-shock protein 90 (Hsp90) inhibitor radicicol for 15min, 30min and 1h. Poly(A) RNA was isolated and sequenced. Kinetics of transcriptional response to Hsp90 inhibition
ORGANISM(S): Drosophila melanogaster 
2012-05-14 | E-GEOD-35812 | biostudies-arrayexpress
ProteomicsLung adenocarcinoma cell lines under HSP90 inhibitors and the proteomic technique iTRAQ
Protein profiling underlying the therapeutic efficacy of HSP90 inhibitors in human lung adenocarcinoma cell lines
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD040170 | Pride
Hsp90 inhibitors Nano lc-ms/ms analysis Human lung adenocarcinoma cell line Itraq labelling 
TranscriptomicsBioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells
Background. Heat shock protein 90 (Hsp90) is essential for the stability and the function of many client proteins, such as ERB2, C-RAF, CDK4, HIF-1 aplha and AKT. Recent reports demonstrated that inhibition of Hsp90 modulates multiple functions required for survival of human cancer, such as myeloma...
ORGANISM(S): Homo sapiens 
2009-05-27 | E-GEOD-12257 | biostudies-arrayexpress
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