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TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
ProteomicsExtracellular vesicles derived from adult and fetal bone marrow mesenchymal stromal cells differentially promote expansion of hematopoietic stem and progenitor cells
Hematopoietic stem cell transplantation (HSCT) is a common practice in the treatment of (malignant-) hematopoietic diseases. Umbilical Cord Blood (UCB) has become an important hematopoietic stem and progenitor cell (HSPC) source for allogeneic HSCT. However, the relatively low number of HSPCs that a...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD022851 | Pride
Extracellular vesicles Bmscs Hspc 
TranscriptomicsmicroRNA expression in murine hematopoietic stem cells
MicroRNAs influence hematopoietic differentiation, but little is known about their effects on the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential for stem cell persistence in vivo and a specific microRNA, miR-125a controls the size of the stem cell population ...
ORGANISM(S): Mus musculus 
2010-08-14 | E-GEOD-22450 | biostudies-arrayexpress
TranscriptomicsKLF7 KO vs WT HSPC expression array
Increased expression of Kruppel like factor 7 (KLF7) is an independent predictor of poor outcome in pediatric acute lymphoblastic leukemia. The contribution of KLF7 to hematopoiesis has not been previously described. Herein, we characterized the effect on murine hematopoiesis of the loss of KLF7 and...
ORGANISM(S): Mus musculus 
2012-08-24 | E-GEOD-40323 | biostudies-arrayexpress
GenomicsMulti-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [RNA-seq]
Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [RNA-seq]
PRJNA493244 | ENA
UnknownTGFβ Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy.
Not available
S-EPMC10416825 | biostudies-literature
GenomicsMulti-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion
Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion
PRJNA493631 | ENA
GenomicsMulti-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [10x]
Multi-dimensional transcriptome analysis of an intact hematopoietic organ for HSPC expansion [10x]
PRJNA493234 | ENA
UnknownBone marrow niche-mimetics modulate HSPC function via integrin signaling.
Not available
S-EPMC5451425 | biostudies-literature
ProteomicsThe E3 Ubiquitin Ligase Cul5 Limits HSPC Expansion and Myeloproliferative Disease in Mice
Myeloproliferative Neoplasms (MPNs) are a heterogenous group of hematologic cancers characterized by excessive JAK/STAT signaling. Mutations of JAK2 signaling components are among the most common drivers of MPN, but alterations in Suppressors of Cytokine Signaling (SOCS) proteins have been implicate...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD046958 | Pride
Myeloproliferative neoplasms Jak2 signaling Hspc expansion Cul5 E3 ubiquitin ligase 
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